Linked Life Data

21618690

Source:http://linkedlifedata.com/resource/pubmed/id/21618690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-5-27
pubmed:abstractText
We show that brief periods of fasting induce functional changes similar to those induced by long-term dietary restriction in mice, and these changes include protection from ischemia/reperfusion (I/R) injury. In this study, we investigated the mechanisms of protection induced by fasting, and we determined the effect on liver regeneration after partial hepatectomy. Partial hepatic ischemia (75 minutes) was induced in ad libitum fed mice and in 1- to 3-day-fasted mice, and one-third or two-thirds hepatectomy was performed in ad libitum fed mice and 3-day-fasted mice. Preoperative fasting for 2 or 3 days significantly decreased hepatocellular I/R injury. Hepatic gene expression of heme oxygenase 1 (HO-1), superoxide dismutase 2 (SOD2), glutathione peroxidase 1 (Gpx1), and glutathione reductase (GSR) was significantly up-regulated in 3-day-fasted mice at the baseline and 6 hours after reperfusion. After reperfusion, p-selectin and interleukin-6 (IL-6) levels were significantly lower, and superoxide radical generation, lipid peroxidation, and neutrophil influx were significantly attenuated in 3-day-fasted mice. Preoperative fasting did not affect liver regeneration after one-third hepatectomy. Hepatic gene expression of IL-6 and transforming growth factor ?1 was significantly higher in 3-day-fasted mice before and after one-third hepatectomy. Tumor necrosis factor ? expression significantly increased after one-third hepatectomy in 3-day-fasted mice. After a 3-day fast and two-thirds hepatectomy, liver regeneration and subsequent postoperative recovery were compromised. In conclusion, up-regulation of the stress response gene HO-1 and the antioxidant enzymes SOD2, Gpx1, and GSR at the baseline and a better response after reperfusion likely underlie the protection induced by fasting against hepatic I/R injury. Preoperative fasting may be a promising new strategy for protecting the liver against I/R injury during liver transplantation and minor liver resections, although its effect on extended hepatectomy warrants further exploration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1527-6473
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 American Association for the Study of Liver Diseases.
pubmed:issnType
Electronic
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
695-704
pubmed:meshHeading
pubmed-meshheading:21618690-Animals, pubmed-meshheading:21618690-Fasting, pubmed-meshheading:21618690-Glutathione Peroxidase, pubmed-meshheading:21618690-Glutathione Reductase, pubmed-meshheading:21618690-Heme Oxygenase-1, pubmed-meshheading:21618690-Hepatectomy, pubmed-meshheading:21618690-Interleukin-6, pubmed-meshheading:21618690-Liver, pubmed-meshheading:21618690-Liver Regeneration, pubmed-meshheading:21618690-Male, pubmed-meshheading:21618690-Mice, pubmed-meshheading:21618690-Mice, Inbred C57BL, pubmed-meshheading:21618690-Models, Animal, pubmed-meshheading:21618690-Preoperative Period, pubmed-meshheading:21618690-Reperfusion Injury, pubmed-meshheading:21618690-Superoxide Dismutase, pubmed-meshheading:21618690-Transforming Growth Factor beta1, pubmed-meshheading:21618690-Up-Regulation
pubmed:year
2011
pubmed:articleTitle
Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration.
pubmed:affiliation
Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't