Source:http://linkedlifedata.com/resource/pubmed/id/21617698
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2011-9-7
|
| pubmed:abstractText |
Monoclonal B-cell lymphocytosis (MBL) is a hematologic condition wherein small B-cell clones can be detected in the blood of asymptomatic individuals. Most MBL have an immunophenotype similar to chronic lymphocytic leukemia (CLL), and 'CLL-like' MBL is a precursor to CLL. We used flow cytometry to identify MBL from unaffected members of CLL kindreds. We identified 101 MBL cases from 622 study subjects; of these, 82 individuals with MBL were further characterized. In all, 91 unique MBL clones were detected: 73 CLL-like MBL (CD5(+)CD20(dim)sIg(dim)), 11 atypical MBL (CD5(+)CD20(+)sIg(+)) and 7 CD5(neg) MBL (CD5(neg)CD20(+)sIg(neg)). Extended immunophenotypic characterization of these MBL subtypes was performed, and significant differences in cell surface expression of CD23, CD49d, CD79b and FMC-7 were observed among the groups. Markers of risk in CLL such as CD38, ZAP70 and CD49d were infrequently expressed in CLL-like MBL, but were expressed in the majority of atypical MBL. Interphase cytogenetics was performed in 35 MBL cases, and del 13q14 was most common (22/30 CLL-like MBL cases). Gene expression analysis using oligonucleotide arrays was performed on seven CLL-like MBL, and showed activation of B-cell receptor associated pathways. Our findings underscore the diversity of MBL subtypes and further clarify the relationship between MBL and other lymphoproliferative disorders.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1476-5551
|
| pubmed:author |
pubmed-author:AchenbachS JSJ,
pubmed-author:AllgoodS DSD,
pubmed-author:BullD FDF,
pubmed-author:CaliT JTJ,
pubmed-author:CaporasoN ENE,
pubmed-author:CerhanJ RJR,
pubmed-author:DaveS SSS,
pubmed-author:GlennMM,
pubmed-author:GockermanJ PJP,
pubmed-author:GoldinL RLR,
pubmed-author:GoodmanB KBK,
pubmed-author:HansonC ACA,
pubmed-author:KayN ENE,
pubmed-author:LanasaM CMC,
pubmed-author:LeisJ FJF,
pubmed-author:LevesqueM CMC,
pubmed-author:LousPP,
pubmed-author:MartiG EGE,
pubmed-author:RabeK GKG,
pubmed-author:RassentiL ZLZ,
pubmed-author:SlagerS LSL,
pubmed-author:SpectorL GLG,
pubmed-author:StromS SSS,
pubmed-author:VachonC MCM,
pubmed-author:WeinbergJ BJB
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1459-66
|
| pubmed:meshHeading |
pubmed-meshheading:21617698-B-Lymphocytes,
pubmed-meshheading:21617698-Flow Cytometry,
pubmed-meshheading:21617698-Gene Expression Profiling,
pubmed-meshheading:21617698-Humans,
pubmed-meshheading:21617698-Immunophenotyping,
pubmed-meshheading:21617698-In Situ Hybridization, Fluorescence,
pubmed-meshheading:21617698-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:21617698-Lymphocytosis,
pubmed-meshheading:21617698-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21617698-Prognosis,
pubmed-meshheading:21617698-RNA, Messenger,
pubmed-meshheading:21617698-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21617698-Tumor Markers, Biological
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL.
|
| pubmed:affiliation |
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. mark.lanasa@duke.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|