rdf:type |
|
lifeskim:mentions |
umls-concept:C0012984,
umls-concept:C0017262,
umls-concept:C0019623,
umls-concept:C0019796,
umls-concept:C0032520,
umls-concept:C0034634,
umls-concept:C0185117,
umls-concept:C0205221,
umls-concept:C0334663,
umls-concept:C0392762,
umls-concept:C0936012,
umls-concept:C1333908,
umls-concept:C1366622,
umls-concept:C1441616,
umls-concept:C2911684
|
pubmed:issue |
5
|
pubmed:dateCreated |
2011-5-27
|
pubmed:abstractText |
Disorders of histiocytic origin affecting humans and dogs share various similarities. Canine disseminated histiocytic sarcoma (DHS) (formerly known as malignant histiocytosis) is an aggressive neoplasm of interstitial dendritic cells (DCs). The receptor for glycation end products (RAGE) and the high mobility group box1 protein (HMGB1) have been shown to be required for the maturation and migration of DCs. Thus, deregulation of the expression of these genes could have a major effect on the progression of histiocytic disorders.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1791-7530
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1541-8
|
pubmed:dateRevised |
2011-8-30
|
pubmed:meshHeading |
pubmed-meshheading:21617208-Animals,
pubmed-meshheading:21617208-Dogs,
pubmed-meshheading:21617208-Down-Regulation,
pubmed-meshheading:21617208-Female,
pubmed-meshheading:21617208-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21617208-HMGB1 Protein,
pubmed-meshheading:21617208-Histiocytic Sarcoma,
pubmed-meshheading:21617208-Immunoenzyme Techniques,
pubmed-meshheading:21617208-Male,
pubmed-meshheading:21617208-RNA, Messenger,
pubmed-meshheading:21617208-Receptors, Immunologic,
pubmed-meshheading:21617208-Reverse Transcriptase Polymerase Chain Reaction
|
pubmed:year |
2011
|
pubmed:articleTitle |
Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis).
|
pubmed:affiliation |
Small Animal Clinic, University of Veterinary Medicine Hannover, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|