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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1990-7-12
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pubmed:abstractText |
Long-term potentiation (LTP) in hippocampus has been proposed to result from a tonic activation of protein kinase C. This hypothesis predicts that stimulation of the kinase would produce a smaller change in response size on potentiated versus control pathways and, conversely, that inhibition of the kinase would reduce potentiated inputs to a greater degree than control responses. We tested these predictions using phorbol esters to activate and using the antagonist H-7 to inhibit protein kinase C; we found that the actions of these drugs on synaptic transmission were not affected by prior induction of LTP. Both compounds, however, significantly decreased the contribution of N-methyl-D-aspartate receptors to synaptic potentials, a result that accounts for the suppressive effects of these compounds on LTP formation. Thus protein kinase C is probably not involved in the expression of LTP but may play a role in the receptor-mediated events participating in its induction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2432432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2549638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2558167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2825923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2830669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2847049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2881605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2899308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2904150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2904701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2905540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-2908443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-3003904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-3010137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-3166141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-3362416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-3697730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-3704635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-4727085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161529-650459
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4073-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2161529-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:2161529-Animals,
pubmed-meshheading:2161529-Hippocampus,
pubmed-meshheading:2161529-Isoquinolines,
pubmed-meshheading:2161529-Membrane Potentials,
pubmed-meshheading:2161529-Neuronal Plasticity,
pubmed-meshheading:2161529-Phorbol Esters,
pubmed-meshheading:2161529-Piperazines,
pubmed-meshheading:2161529-Protein Kinase C,
pubmed-meshheading:2161529-Rats,
pubmed-meshheading:2161529-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:2161529-Receptors, Neurotransmitter,
pubmed-meshheading:2161529-Synaptic Transmission,
pubmed-meshheading:2161529-Time Factors
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pubmed:year |
1990
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pubmed:articleTitle |
Protein kinase C activity is not responsible for the expression of long-term potentiation in hippocampus.
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pubmed:affiliation |
Department of Pharmacology, Centre Medical Universitaire, Geneva, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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