|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
1990-7-12
|
|
pubmed:abstractText |
1. Zinc is taken up into human red cells by two mechanisms that depend upon the presence of anions. One of these requires bicarbonate ions, is inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS) and appears to be catalysed by the anion exchanger. The second occurs in the presence of thiocyanate or salicylate ions and may represent transport of a neutral complex with Zn2+. 2. The initial rate of Zn2+ uptake via the anion exchanger is 64 +/- 13 mumol (10(13) cells x h)-1 microM-1 external Zn2+, in the presence of 5 mM-bicarbonate at pH 7.4 and 37 degrees C (+/- S.D.). This is about 1/250 of the corresponding rate of Pb2+ uptake by the anion exchanger. 3. The variation of transport with Zn2+ concentration, HCO3- concentration and pH suggests that the transported species may be ZnCO3Cl- or Zn(HCO3)Cl.OH-. 4. Zinc efflux could not be observed by either of the above routes. This observation suggests that the intracellular free Zn2+ concentration is below 3 nM.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-19556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-24784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-2918033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-2956262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-3025431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-31458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-3335537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-3533646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-3795106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-3918596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-430388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-4688320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-5431014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-5499736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-5499737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-5543683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-5584526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-6206098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-7213700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161459-75027
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4,4'-Diisothiocyanostilbene-2,2'-Dis...,
http://linkedlifedata.com/resource/pubmed/chemical/4-Acetamido-4'-isothiocyanatostilben...,
http://linkedlifedata.com/resource/pubmed/chemical/Anions,
http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates,
http://linkedlifedata.com/resource/pubmed/chemical/Cations, Divalent,
http://linkedlifedata.com/resource/pubmed/chemical/Cations, Monovalent,
http://linkedlifedata.com/resource/pubmed/chemical/Lead,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc,
http://linkedlifedata.com/resource/pubmed/chemical/thiocyanate
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-3751
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
421
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
485-97
|
|
pubmed:dateRevised |
2010-8-25
|
|
pubmed:meshHeading |
pubmed-meshheading:2161459-4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid,
pubmed-meshheading:2161459-4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid,
pubmed-meshheading:2161459-Anions,
pubmed-meshheading:2161459-Bicarbonates,
pubmed-meshheading:2161459-Cations, Divalent,
pubmed-meshheading:2161459-Cations, Monovalent,
pubmed-meshheading:2161459-Erythrocyte Membrane,
pubmed-meshheading:2161459-Humans,
pubmed-meshheading:2161459-Lead,
pubmed-meshheading:2161459-Salicylic Acid,
pubmed-meshheading:2161459-Salicylic Acids,
pubmed-meshheading:2161459-Thiocyanates,
pubmed-meshheading:2161459-Zinc
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Anionic mechanisms of zinc uptake across the human red cell membrane.
|
|
pubmed:affiliation |
Biomedical Sciences Division, King's College London, Strand.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
