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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-8-26
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pubmed:abstractText |
The role of the cerebellum in coordinating mental activity is supported by its connections with cerebral regions involved in cognitive/affective functioning, with decreased activities on functional neuroimaging observed in the cerebellum of schizophrenia patients performing mental tasks. Brain-derived neurotrophic factor (BDNF)-induced activation of tyrosine kinase B (TrkB) is essential to synaptic plasticity. We hypothesized that alterations in BDNF and TrkB expression in the cerebellum were associated with schizophrenia and affective disorders.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/DA12065,
http://linkedlifedata.com/resource/pubmed/grant/DA26306,
http://linkedlifedata.com/resource/pubmed/grant/DA26334,
http://linkedlifedata.com/resource/pubmed/grant/DA27513,
http://linkedlifedata.com/resource/pubmed/grant/MH62512,
http://linkedlifedata.com/resource/pubmed/grant/MH74508,
http://linkedlifedata.com/resource/pubmed/grant/MH76681,
http://linkedlifedata.com/resource/pubmed/grant/MH78728,
http://linkedlifedata.com/resource/pubmed/grant/MH79728,
http://linkedlifedata.com/resource/pubmed/grant/MH79881,
http://linkedlifedata.com/resource/pubmed/grant/MH81482,
http://linkedlifedata.com/resource/pubmed/grant/MH81861,
http://linkedlifedata.com/resource/pubmed/grant/MH83506,
http://linkedlifedata.com/resource/pubmed/grant/MH85560,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA026334-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH079881-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH081861-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH085560-04,
http://linkedlifedata.com/resource/pubmed/grant/R03 DA027513-02,
http://linkedlifedata.com/resource/pubmed/grant/R21 MH078728-01A2,
http://linkedlifedata.com/resource/pubmed/grant/R25 MH074508-04,
http://linkedlifedata.com/resource/pubmed/grant/R25 MH081482-02,
http://linkedlifedata.com/resource/pubmed/grant/R41 MH079728-01A1
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1573-2517
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
646-54
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pubmed:meshHeading |
pubmed-meshheading:21612826-Adult,
pubmed-meshheading:21612826-Bipolar Disorder,
pubmed-meshheading:21612826-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:21612826-Case-Control Studies,
pubmed-meshheading:21612826-Cerebellum,
pubmed-meshheading:21612826-Depressive Disorder, Major,
pubmed-meshheading:21612826-Female,
pubmed-meshheading:21612826-Hippocampus,
pubmed-meshheading:21612826-Humans,
pubmed-meshheading:21612826-Male,
pubmed-meshheading:21612826-Middle Aged,
pubmed-meshheading:21612826-Nerve Growth Factors,
pubmed-meshheading:21612826-Neurons,
pubmed-meshheading:21612826-Protein Isoforms,
pubmed-meshheading:21612826-Protein-Tyrosine Kinases,
pubmed-meshheading:21612826-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21612826-Receptor, trkB,
pubmed-meshheading:21612826-Schizophrenia,
pubmed-meshheading:21612826-Signal Transduction,
pubmed-meshheading:21612826-Tyrosine
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pubmed:year |
2011
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pubmed:articleTitle |
Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder.
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pubmed:affiliation |
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093-0603, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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