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pubmed-article:21612823pubmed:dateCreated2011-8-15lld:pubmed
pubmed-article:21612823pubmed:abstractTextThe interaction between dendritic cells (DCs) and natural killer (NK) cells plays a key role in inducing DC maturation for subsequent T-cell priming. We investigated to generate potent DCs by stimulated with NK cells to induce myeloma-specific cytotoxic T lymphocytes (CTLs). NK cells-stimulated-DCs exhibited high expression of costimulatory molecules and high production of IL-12p70. These DCs induce high potency of Th1 polarization and exhibit a high ability to generate myeloma-specific CTLs responses. These results suggest that functionally potent DCs can be generated by stimulation with NK cells and may provide an effective source of DC-based immunotherapy in multiple myeloma.lld:pubmed
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pubmed-article:21612823pubmed:authorpubmed-author:LeeHyun JuHJlld:pubmed
pubmed-article:21612823pubmed:authorpubmed-author:LeeJe-JungJJlld:pubmed
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pubmed-article:21612823pubmed:authorpubmed-author:LeeYoun-Kyung...lld:pubmed
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pubmed-article:21612823pubmed:authorpubmed-author:NguyenTruc-An...lld:pubmed
pubmed-article:21612823pubmed:copyrightInfoCopyright © 2011 Elsevier Ltd. All rights reserved.lld:pubmed
pubmed-article:21612823pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21612823pubmed:volume35lld:pubmed
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pubmed-article:21612823pubmed:pagination1241-7lld:pubmed
pubmed-article:21612823pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:21612823pubmed:year2011lld:pubmed
pubmed-article:21612823pubmed:articleTitleInduction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma.lld:pubmed
pubmed-article:21612823pubmed:affiliationResearch Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeollanamdo, Hwasun, Republic of Korea.lld:pubmed
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