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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-15
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pubmed:abstractText |
The interaction between dendritic cells (DCs) and natural killer (NK) cells plays a key role in inducing DC maturation for subsequent T-cell priming. We investigated to generate potent DCs by stimulated with NK cells to induce myeloma-specific cytotoxic T lymphocytes (CTLs). NK cells-stimulated-DCs exhibited high expression of costimulatory molecules and high production of IL-12p70. These DCs induce high potency of Th1 polarization and exhibit a high ability to generate myeloma-specific CTLs responses. These results suggest that functionally potent DCs can be generated by stimulation with NK cells and may provide an effective source of DC-based immunotherapy in multiple myeloma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1873-5835
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pubmed:author |
pubmed-author:AhnJae-SookJS,
pubmed-author:ChoDuckD,
pubmed-author:ChungIk-JooIJ,
pubmed-author:HongCheol YiCY,
pubmed-author:ImChang-MinCM,
pubmed-author:KimHyeoung-JoonHJ,
pubmed-author:KimMi-HyunMH,
pubmed-author:KimYeo-KyeoungYK,
pubmed-author:LeeHyun JuHJ,
pubmed-author:LeeJe-JungJJ,
pubmed-author:LeeYoun-KyungYK,
pubmed-author:LimMi-SeonMS,
pubmed-author:Nguyen-PhamThanh-NhanTN,
pubmed-author:NguyenTruc-Anh ThiTA,
pubmed-author:YangDeok-HwanDH
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1241-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21612823-Cell Polarity,
pubmed-meshheading:21612823-Cell Proliferation,
pubmed-meshheading:21612823-Cells, Cultured,
pubmed-meshheading:21612823-Cytotoxicity, Immunologic,
pubmed-meshheading:21612823-Dendritic Cells,
pubmed-meshheading:21612823-HL-60 Cells,
pubmed-meshheading:21612823-Humans,
pubmed-meshheading:21612823-Interferon Type I,
pubmed-meshheading:21612823-K562 Cells,
pubmed-meshheading:21612823-Killer Cells, Natural,
pubmed-meshheading:21612823-Lymphocyte Activation,
pubmed-meshheading:21612823-Multiple Myeloma,
pubmed-meshheading:21612823-Polydeoxyribonucleotides,
pubmed-meshheading:21612823-Recombinant Proteins,
pubmed-meshheading:21612823-T-Cell Antigen Receptor Specificity,
pubmed-meshheading:21612823-T-Lymphocytes, Cytotoxic
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pubmed:year |
2011
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pubmed:articleTitle |
Induction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma.
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pubmed:affiliation |
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeollanamdo, Hwasun, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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