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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-6-30
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pubmed:abstractText |
BACK GROUND: Chandipura virus produces acute infection in mice. During infection drastic reduction of CD4+, CD8+ and CD19 + cell was noticed. Depletion of lymphocytes also noticed in spleen. The reduction may be due to the regulatory mechanism of immune system to prevent the bystander host tissue injury. There are several mechanisms like generation of regulatory cells, activation induced cell death (ACID) etc were indicated to control the activation and maintain cellular homeostasis. Role of regulatory cells in homeostasis has been described in several viral diseases. This study was undertaken to characterize CD4+T regulatory cells from the infected mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-10850488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-11940113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-12612578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-1396582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-14597769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-15196254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-15351194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-15520849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-16006607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-16382236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-17195077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-17440051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-17868872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-18160439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-18182120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-18830259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-4718198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-4970067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21612593-6464425
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/IL10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Il2ra protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor alpha
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pubmed:status |
MEDLINE
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pubmed:issn |
1743-422X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21612593-Animals,
pubmed-meshheading:21612593-Antigens, CD,
pubmed-meshheading:21612593-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21612593-CTLA-4 Antigen,
pubmed-meshheading:21612593-Cell Proliferation,
pubmed-meshheading:21612593-Disease Models, Animal,
pubmed-meshheading:21612593-Flow Cytometry,
pubmed-meshheading:21612593-Forkhead Transcription Factors,
pubmed-meshheading:21612593-Interleukin-10,
pubmed-meshheading:21612593-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:21612593-Interleukin-7 Receptor alpha Subunit,
pubmed-meshheading:21612593-Mice,
pubmed-meshheading:21612593-Mice, Inbred BALB C,
pubmed-meshheading:21612593-Rhabdoviridae Infections,
pubmed-meshheading:21612593-Rodent Diseases,
pubmed-meshheading:21612593-T-Lymphocytes, Regulatory,
pubmed-meshheading:21612593-Transforming Growth Factor alpha,
pubmed-meshheading:21612593-Vesiculovirus
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pubmed:year |
2011
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pubmed:articleTitle |
Immune regulation in Chandipura virus infection: characterization of CD4+ T regulatory cells from infected mice.
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pubmed:affiliation |
Chandipura Virus Group, National Institute of Virology, Pune-411001, India. anukumar_b74@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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