Source:http://linkedlifedata.com/resource/pubmed/id/21612546
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2011-5-26
|
| pubmed:abstractText |
The purpose of this study was to evaluate retrospectively the potential benefits of directly administered antiretroviral therapy (DAART) in HIV-infected former injecting drug users (ex-IDUs) admitted to residential drug rehabilitation facilities. We compared 106 of these patients consecutively admitted in 12 communities where DAART was administered (DAART group) to two matched control groups of ex-IDUs undergoing self-administered ART: 106 subjects in other 10 communities (SAT group) and 106 outpatients at hospital infectious-disease wards where community patients were referred after discharge (OUT group). We estimated the proportion of patients with high adherence and the hazard ratio (HR) of 20% or more increase in the CD4(+) cell count and of reaching an undetectable viral load. The proportion of patients with high adherence to treatment was highest in the DAART group. The probability of 20% or more increase in the CD4(+) cell count was significantly lower in the two control groups versus the DAART group (SAT group HR=0.32; OUT group HR=0.43). The HR of observing an undetectable HIV-RNA level versus DAART was significantly lower in the OUT group (HR: 0.71; 95% confidence interval [CI]: 0.52-0.97) but did not reach statistical significance for the SAT group (HR: 0.99; 95% CI: 0.74-1.33). Our findings after a 24-month follow-up, suggest that DAART in HIV-infected patients of drug-rehabilitation communities improves adherence, immunologic, and virologic outcome toward free outpatients. Even if our retrospective 36-month data do not show a prolonged viral suppression in these patients, DAART may be considered a valuable therapeutic and educational strategy in this particular target group.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1557-7449
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| pubmed:author |
pubmed-author:BabudieriSergioS,
pubmed-author:BoschiniAntonioA,
pubmed-author:CarbonaraSergioS,
pubmed-author:CaselliFrancescaF,
pubmed-author:CongedoPierpaoloP,
pubmed-author:DorrucciMariaM,
pubmed-author:LongoBenedettaB,
pubmed-author:MadedduGiordanoG,
pubmed-author:MaidaIvana RitaIR,
pubmed-author:MonarcaRobertoR,
pubmed-author:OrtuFrancescoF,
pubmed-author:RezzaGiovanniG,
pubmed-author:SodduAndreaA
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
359-64
|
| pubmed:meshHeading |
pubmed-meshheading:21612546-Adult,
pubmed-meshheading:21612546-Anti-HIV Agents,
pubmed-meshheading:21612546-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:21612546-CD4 Lymphocyte Count,
pubmed-meshheading:21612546-Directly Observed Therapy,
pubmed-meshheading:21612546-Female,
pubmed-meshheading:21612546-Follow-Up Studies,
pubmed-meshheading:21612546-HIV Infections,
pubmed-meshheading:21612546-Humans,
pubmed-meshheading:21612546-Logistic Models,
pubmed-meshheading:21612546-Male,
pubmed-meshheading:21612546-Patient Compliance,
pubmed-meshheading:21612546-Proportional Hazards Models,
pubmed-meshheading:21612546-RNA, Viral,
pubmed-meshheading:21612546-Retrospective Studies,
pubmed-meshheading:21612546-Substance Abuse, Intravenous,
pubmed-meshheading:21612546-Substance Abuse Treatment Centers,
pubmed-meshheading:21612546-Treatment Outcome,
pubmed-meshheading:21612546-Viral Load
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Targeting candidates for directly administered highly active antiretroviral therapy: benefits observed in HIV-infected injecting drug users in residential drug-rehabilitation facilities.
|
| pubmed:affiliation |
Institute of Infectious Diseases, University of Sassari, Italy. babuder@uniss.it
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Evaluation Studies
|