| pubmed-article:21612404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0082420 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C1366583 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0002638 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0013303 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C1655731 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C1332712 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0242303 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21612404 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21612404 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:21612404 | pubmed:dateCreated | 2011-9-12 | lld:pubmed |
| pubmed-article:21612404 | pubmed:abstractText | Pancreatic and duodenal homeobox factor 1 (PDX-1) maintains ?-cell function and differentiation via direct regulation of multiple islet cell genes. However, the molecular mechanisms involved in this process remain unknown. Here, we show that PDX-1 plays an important role in the induction of CD44+/CD105+ human amniotic fluid cells (HuAFCs) into functional pancreatic ?-cell-like cells in vitro. CD44+/CD105+ HuAFCs were transfected with either siRNA targeting PDX-1 (siRNA-PDX-1) or mock plasmid (siRNA-MOCK). Following induction, siRNA-MOCK-transfected cells differentiated into ?-cell-like cells that expressed multiple islet cell markers and produced insulin and C-peptide in a glucose-regulated manner. However, siRNA-PDX-1-transfected cells did not fully differentiate into ?-cell-like cells. Further, we observed epigenetic changes at the PDX-1 gene locus in induced CD44(+)/CD105(+) HuAFCs. Therefore, CD44+/CD105+ HuAFCs could be a source of human pancreatic ?-cell-like cells with potential uses in cell replacement therapy for diabetes. | lld:pubmed |
| pubmed-article:21612404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21612404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21612404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21612404 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:21612404 | pubmed:issn | 1557-7430 | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:KoçLL | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:LiuYanY | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:ZhangLifanL | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:GuoLiheL | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:LiuZhixueZ | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:ZouGangG | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:LaiLiL | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:DuXilingX | lld:pubmed |
| pubmed-article:21612404 | pubmed:author | pubmed-author:XuFuhuiF | lld:pubmed |
| pubmed-article:21612404 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21612404 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:21612404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21612404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21612404 | pubmed:pagination | 739-48 | lld:pubmed |
| pubmed-article:21612404 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
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| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:meshHeading | pubmed-meshheading:21612404... | lld:pubmed |
| pubmed-article:21612404 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21612404 | pubmed:articleTitle | Induction of pancreatic ?-cell-like cells from CD44+/CD105+ human amniotic fluids via epigenetic regulation of the pancreatic and duodenal homeobox factor 1 promoter. | lld:pubmed |
| pubmed-article:21612404 | pubmed:affiliation | Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China. | lld:pubmed |
| pubmed-article:21612404 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21612404 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:21612404 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3651 | entrezgene:pubmed | pubmed-article:21612404 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21612404 | lld:entrezgene |
