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pubmed-article:2161219pubmed:abstractTextPC-12 pheochromocytoma cells contain a growth factor-sensitive protein kinase that phosphorylates microtubule associated protein 2 (MAP-2). This MAP kinase is also activated by the protein phosphatase inhibitor okadaic acid (OA). Additionally, OA potentiates the NGF-dependent activation of MAP kinase, but causes only a modest potentiation (20%) of the maximal activation observed with EGF. Since OA is a specific serine/threonine phosphatase inhibitor, these results suggest that serine/threonine phosphorylation may be involved in the hormonal regulation of MAP kinase.lld:pubmed
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pubmed-article:2161219pubmed:articleTitleOkadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells.lld:pubmed
pubmed-article:2161219pubmed:affiliationLaboratory of Molecular Oncology, Rockefeller University, New York, New York 10021.lld:pubmed
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pubmed-article:2161219pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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