Linked Life Data

21609130

Source:http://linkedlifedata.com/resource/pubmed/id/21609130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-7-27
pubmed:abstractText
Synthesis of multifunctional hybrid nanomaterials for biomedical applications has received great attention. Herein, we examine the potential toxicity of organophyllosilicates on cells from different organs such as A549 (lung epithelial cancer), HT-29 (colon epithelial cancer), MRC-5 (lung fibroblast) and CCD-986sk (skin fibroblast) cells. For this, aminopropyl functionalized magnesium phyllosilicate (AMP clay) and aminopropyl functionalized calcium phyllosilicate (ACP clay) were prepared using one-pot direct sol-gel method. Toxic effects of these organoclays on normal fibroblast and tumor cells were examined under varying concentrations and exposure times. MTT and LDH assays indicated that both organoclays had little cytotoxicity in all of the cells tested at concentrations as high as 500 ?g/mL. Even at high concentration (1000 ?g/mL), the toxicity of both organoclays on cell viability and membrane damage was not severe and appeared to be cell type specific. In addition, organoclays did not induce apoptosis at concentrations as high as 1000 ?g/mL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1944-8252
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2564-72
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Magnesium and calcium organophyllosilicates: synthesis and in vitro cytotoxicity study.
pubmed:affiliation
College of Pharmacy, Dongguk University , Pil-dong, 3-ga, Jung-gu, Seoul, Republic of Korea.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't