Linked Life Data

21606479

Source:http://linkedlifedata.com/resource/pubmed/id/21606479

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-7-22
pubmed:abstractText
Unlike conventional T cells, which are exported from the thymus as naive cells and acquire effector functions upon antigen encounter in the periphery, a subset of ?? T cells differentiates into effectors that produce IL-17 within the fetal thymus. We demonstrate here that intrathymic development of the naturally occurring IL-17-producing ?? T cells is independent of STAT3 and partly dependent on ROR?t. Comparative gene-expression analysis identified Hes1, one of the basic helix-loop-helix proteins involved in Notch signaling, as a factor specifically expressed in IL-17-producing ?? T cells. Hes1 is critically involved in the development of IL-17-producing ?? T cells, as evidenced by their severe decrease in the thymi of Hes1-deficient fetal mice. Delta-like 4 (Dll4)-expressing stromal cells support the development of IL-17-producing ?? T cells in vitro. In addition, conditional Hes1 ablation in peripheral ?? T cells decreases their IL-17 production but not their IFN-? production. These results reveal a unique differentiation pathway of IL-17-producing ?? T cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
586-93
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Notch-Hes1 pathway is required for the development of IL-17-producing ?? T cells.
pubmed:affiliation
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan. k_shibata@bioreg.kyushu-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't