Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-6-28
pubmed:abstractText
The effects of clonidine on the vagal reflex-induced tracheal constriction have been investigated in anesthetized, paralyzed, and artificially ventilated mongrel dogs. The cervical trachea was transected in situ into two parts. Responses of the tracheal musculature were measured as changes in the intratracheal pressure on an air-filled balloon introduced into the rostral side of the transected trachea. Reflex tracheal constriction was induced by afferent electrical stimulation at the central cut end of the vagus nerve. Drugs were injected or infused close intraarterially (i.a.) into the bilateral cranial thyroid arteries in such a way that each drug was applied just to the rostral trachea. The reflex tracheal constriction was abolished by a close i.a. infusion of 3 microM atropine. The magnitude of the reflex tracheal constriction was slightly reduced by a close i.a. infusion of 10 microM clonidine and was significantly reduced by the infusion of clonidine at a concentration of 100 and 300 microM. The response to 100 microM clonidine was antagonized by a close i.a. infusion of 1 microM yohimbine. The tracheal constriction induced by i.a. injection of 5.5 nmol acetylcholine was unaffected by infusion of 10, 100 and 300 microM clonidine. The vagal reflex-induced tracheal constriction seems to be inhibited by stimulation of prejunctional alpha 2-adrenoceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0386-846X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
30-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2160528-Acetylcholine, pubmed-meshheading:2160528-Animals, pubmed-meshheading:2160528-Blood Pressure, pubmed-meshheading:2160528-Clonidine, pubmed-meshheading:2160528-Dogs, pubmed-meshheading:2160528-Dose-Response Relationship, Drug, pubmed-meshheading:2160528-Electric Stimulation, pubmed-meshheading:2160528-Heart Rate, pubmed-meshheading:2160528-Infusions, Intra-Arterial, pubmed-meshheading:2160528-Injections, Intra-Arterial, pubmed-meshheading:2160528-Male, pubmed-meshheading:2160528-Muscle, Smooth, pubmed-meshheading:2160528-Muscle Contraction, pubmed-meshheading:2160528-Receptors, Adrenergic, alpha, pubmed-meshheading:2160528-Reflex, pubmed-meshheading:2160528-Trachea, pubmed-meshheading:2160528-Tracheal Stenosis, pubmed-meshheading:2160528-Vagus Nerve, pubmed-meshheading:2160528-Yohimbine
pubmed:year
1990
pubmed:articleTitle
Involvement of alpha 2-adrenergic receptors in the vagal reflex-induced tracheal constriction.
pubmed:affiliation
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't