rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-6-28
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pubmed:abstractText |
Fructose-1, 6-diphosphate (FDP) decreases the effect of ethanol on Ca++ entry and inhibits the ethanol-stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol-stimulated [36Cl-]-uptake by rat brain microvesicles and affects the isolated GABA-receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose-dependent decrease in ethanol-induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Fructosediphosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Hexosediphosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/Transaminases,
http://linkedlifedata.com/resource/pubmed/chemical/fructose-1,6-diphosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0263-6484
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-47
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2160337-Animals,
pubmed-meshheading:2160337-Brain,
pubmed-meshheading:2160337-Calcium,
pubmed-meshheading:2160337-Chlorides,
pubmed-meshheading:2160337-Diuresis,
pubmed-meshheading:2160337-Ethanol,
pubmed-meshheading:2160337-Fructosediphosphates,
pubmed-meshheading:2160337-Hexosediphosphates,
pubmed-meshheading:2160337-Male,
pubmed-meshheading:2160337-Myocardium,
pubmed-meshheading:2160337-Peptic Ulcer,
pubmed-meshheading:2160337-Phosphorus,
pubmed-meshheading:2160337-Rats,
pubmed-meshheading:2160337-Rats, Inbred Strains,
pubmed-meshheading:2160337-Receptors, GABA-A,
pubmed-meshheading:2160337-Substance Withdrawal Syndrome,
pubmed-meshheading:2160337-Transaminases
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pubmed:year |
1990
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pubmed:articleTitle |
Fructose-1,6-diphosphate as an in vitro and in vivo anti-alcohol agent in the rat.
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pubmed:affiliation |
Department of Biological Chemistry, University of Padova, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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