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rdf:type |
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lifeskim:mentions |
umls-concept:C0021311,
umls-concept:C0023820,
umls-concept:C0026926,
umls-concept:C0205263,
umls-concept:C0332281,
umls-concept:C0871261,
umls-concept:C1423842,
umls-concept:C1545588,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:dateCreated |
2011-5-23
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pubmed:abstractText |
The M. tuberculosis phosphate-binding transporter lipoproteins PstS1 and PstS3 were good immunogens inducing CD8(+) T-cell activation and both Th1 and Th17 immunity in mice. However, this antigen-specific immunity, even when amplified by administration of the protein with the adjuvant LTK63 or by the DNA priming/protein boosting regimen, was not able to contain M. tuberculosis replication in the lungs of infected mice. The lack of protection might be ascribed with the scarce/absent capacity of PstS1/PstS3 antigens to modulate the IFN-? response elicited by M. tuberculosis infection during which, however, PstS1-specific IL-17 secreting cells were generated in both unvaccinated and BCG-vaccinated mice. In spite of a lack of protection by PstS1/PstS3 immunizations, our results do show that PstS1 is able to induce IL-17 response upon M. tuberculosis infection which is of interest in the study of anti-M. tuberculosis immunity and as potential immunomodulator in combined vaccines.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-10529776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-10978546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-11748285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-12718935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-1379565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-1396968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-14766880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-15731097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-16200068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-16200070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-16849446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-17056566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-17250590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-17351619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-17483450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-17534845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-18584925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-19505813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-20624887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-20679438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-7512931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-8245795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-9041387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-9180075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-9190945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-9634230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21603219-9916741
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/BCG Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Tuberculosis Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/antigen 85B, Mycobacterium...
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pubmed:status |
MEDLINE
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pubmed:issn |
1740-2530
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2011
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
690328
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pubmed:meshHeading |
pubmed-meshheading:21603219-Acyltransferases,
pubmed-meshheading:21603219-Animals,
pubmed-meshheading:21603219-Antigens, Bacterial,
pubmed-meshheading:21603219-BCG Vaccine,
pubmed-meshheading:21603219-Bacterial Load,
pubmed-meshheading:21603219-Bacterial Proteins,
pubmed-meshheading:21603219-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21603219-Epitopes,
pubmed-meshheading:21603219-Female,
pubmed-meshheading:21603219-Immunization,
pubmed-meshheading:21603219-Immunologic Memory,
pubmed-meshheading:21603219-Interferon-gamma,
pubmed-meshheading:21603219-Interleukin-17,
pubmed-meshheading:21603219-Mice,
pubmed-meshheading:21603219-Mice, Inbred C57BL,
pubmed-meshheading:21603219-Mycobacterium tuberculosis,
pubmed-meshheading:21603219-Th1 Cells,
pubmed-meshheading:21603219-Th17 Cells,
pubmed-meshheading:21603219-Tuberculosis,
pubmed-meshheading:21603219-Tuberculosis Vaccines
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pubmed:year |
2011
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pubmed:articleTitle |
The M. tuberculosis phosphate-binding lipoproteins PstS1 and PstS3 induce Th1 and Th17 responses that are not associated with protection against M. tuberculosis infection.
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pubmed:affiliation |
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. c.palma@iss.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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