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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-9-16
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pubmed:abstractText |
Intact antibodies are poor imaging agents due to a long serum half-life (10-20 d) preventing adequate contrast between the tumor and surrounding blood. Smaller engineered antibody fragments overcome this problem by exhibiting shorter serum half-lives (4-20 h).The diabody (55 kDa) is the smallest antibody fragment, which retains the bivalency of the intact antibody. Our goal was to develop and characterize the anti-CA19-9 diabody fragment and determine its ability to provide antigen specific imaging of pancreas cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:copyrightInfo |
Published by Elsevier Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-78
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pubmed:meshHeading |
pubmed-meshheading:21601881-Animals,
pubmed-meshheading:21601881-Antibodies, Monoclonal,
pubmed-meshheading:21601881-Antibody Specificity,
pubmed-meshheading:21601881-CA-19-9 Antigen,
pubmed-meshheading:21601881-Cell Line, Tumor,
pubmed-meshheading:21601881-Disease Models, Animal,
pubmed-meshheading:21601881-Flow Cytometry,
pubmed-meshheading:21601881-Humans,
pubmed-meshheading:21601881-Hybridomas,
pubmed-meshheading:21601881-Immunoglobulin Fragments,
pubmed-meshheading:21601881-Iodine Radioisotopes,
pubmed-meshheading:21601881-Mice,
pubmed-meshheading:21601881-Multiple Myeloma,
pubmed-meshheading:21601881-Pancreatic Neoplasms,
pubmed-meshheading:21601881-Positron-Emission Tomography,
pubmed-meshheading:21601881-Protein Engineering,
pubmed-meshheading:21601881-Tissue Distribution,
pubmed-meshheading:21601881-Transplantation, Heterologous
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pubmed:year |
2011
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pubmed:articleTitle |
Anti-CA19-9 diabody as a PET imaging probe for pancreas cancer.
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pubmed:affiliation |
Department of Surgery, UCLA, Los Angeles, California 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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