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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2011-6-21
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pubmed:abstractText |
Rapamycin (sirolimus) is an antibiotic that inhibits protein synthesis through mammalian targeting of rapamycin (mTOR) signaling, and is used as an immunosuppressant in the treatment of organ rejection in transplant recipients. Rapamycin confers preconditioning-like protection against ischemic-reperfusion injury in isolated mouse heart cultures. Our aim was to further define the role of rapamycin in intracellular Ca(2+) homeostasis and to investigate the mechanism by which rapamycin protects cardiomyocytes from hypoxic damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1879-0631
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7-14
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pubmed:meshHeading |
pubmed-meshheading:21600903-Animals,
pubmed-meshheading:21600903-Calcium,
pubmed-meshheading:21600903-Cell Hypoxia,
pubmed-meshheading:21600903-Cells, Cultured,
pubmed-meshheading:21600903-Creatine Kinase,
pubmed-meshheading:21600903-Dose-Response Relationship, Drug,
pubmed-meshheading:21600903-Homeostasis,
pubmed-meshheading:21600903-L-Lactate Dehydrogenase,
pubmed-meshheading:21600903-Rats,
pubmed-meshheading:21600903-Reperfusion Injury,
pubmed-meshheading:21600903-Sarcoplasmic Reticulum,
pubmed-meshheading:21600903-Sirolimus,
pubmed-meshheading:21600903-Sodium-Calcium Exchanger,
pubmed-meshheading:21600903-Tetrazolium Salts,
pubmed-meshheading:21600903-Thiazoles,
pubmed-meshheading:21600903-Thiourea,
pubmed-meshheading:21600903-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Rapamycin (sirolimus) protects against hypoxic damage in primary heart cultures via Na+/Ca2+ exchanger activation.
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pubmed:affiliation |
Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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