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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-7-4
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pubmed:abstractText |
The natural killer group 2 member D (NKG2D) is a stimulatory receptor expressed on a subset of mucosal and peripheral CD4+ T cells in patients with Crohn's disease (CD) and other inflammatory diseases. Ligand activation of NKG2D in patients induces CD4+ T cells to release T-helper (Th) 1 cytokines and become cytotoxic. We investigated the Th17 cytokines produced by T cells that express NKG2D in blood and intestinal mucosa samples from patients with CD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/KLRB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KLRK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:AllezMatthieuM,
pubmed-author:CamusMatthieuM,
pubmed-author:CattanPierreP,
pubmed-author:CharronDominiqueD,
pubmed-author:DulphyNicolasN,
pubmed-author:DutertreCharles-AntoineCA,
pubmed-author:EtterspergerJulienJ,
pubmed-author:GornetJean-MarcJM,
pubmed-author:LémannMarcM,
pubmed-author:MocanIuliaI,
pubmed-author:ParienteBenjaminB,
pubmed-author:ToubertAntoineA
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-26, 226.e1-2
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pubmed:meshHeading |
pubmed-meshheading:21600899-Adolescent,
pubmed-meshheading:21600899-Adult,
pubmed-meshheading:21600899-Animals,
pubmed-meshheading:21600899-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21600899-Case-Control Studies,
pubmed-meshheading:21600899-Cell Line, Tumor,
pubmed-meshheading:21600899-Colitis, Ulcerative,
pubmed-meshheading:21600899-Crohn Disease,
pubmed-meshheading:21600899-Cytokines,
pubmed-meshheading:21600899-Female,
pubmed-meshheading:21600899-Flow Cytometry,
pubmed-meshheading:21600899-France,
pubmed-meshheading:21600899-Humans,
pubmed-meshheading:21600899-Immunophenotyping,
pubmed-meshheading:21600899-Inflammation Mediators,
pubmed-meshheading:21600899-Intestinal Mucosa,
pubmed-meshheading:21600899-Ligands,
pubmed-meshheading:21600899-Male,
pubmed-meshheading:21600899-Mice,
pubmed-meshheading:21600899-Middle Aged,
pubmed-meshheading:21600899-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:21600899-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:21600899-Phenotype,
pubmed-meshheading:21600899-Receptors, Antigen, T-Cell,
pubmed-meshheading:21600899-Th17 Cells,
pubmed-meshheading:21600899-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease.
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pubmed:affiliation |
INSERM, Equipe AVENIR U940 Hôpital Saint-Louis, and Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris 6, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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