Linked Life Data

21600570

Source:http://linkedlifedata.com/resource/pubmed/id/21600570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-7-4
pubmed:abstractText
Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myeloid-derived suppressor cells (MDSC) compared to patients with lower stress. PBMC from 16 patients with high stress (n = 8) or with low stress (n = 8) after surgery as measured by the Impact of Event Scale (IES) questionnaire were evaluated for the presence of MDSC. Patients with higher IES scores had significantly elevated salivary cortisol levels (P = 0.013; 13 ?g/dl vs. 9.74 ?g/dl). Levels of IL-1R? were also significantly elevated in the higher IES group (45.09 pg/ml vs. 97.16 pg/ml; P = 0.010). IP 10, G-CSF, and IL-6 were all higher in the high stress group although not to a significant degree. Flow cytometric analysis for CD33+/HLA-DR-neg/CD15+/CD11b+ MDSC revealed increased MDSC in patients with lower IES scores (P = 0.009). CD11b+/CD15+ cells constituted 9.4% of the CD33+/HLA DR-neg cell population in patients with high IES, vs. 27.3% in patients with low IES scores. Additional analyzes of the number of stressful events that affected the patients in addition to their cancer diagnosis revealed that this type of stress measure correlated with elevated levels of MDSC (P = 0.064). These data indicate the existence of a complex relationship between stress and immune function in breast cancer patients.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/K05 CA098133, http://linkedlifedata.com/resource/pubmed/grant/K05 CA098133-07, http://linkedlifedata.com/resource/pubmed/grant/K24 CA093670-10, http://linkedlifedata.com/resource/pubmed/grant/K24 CA93670, http://linkedlifedata.com/resource/pubmed/grant/M01 RR0034, http://linkedlifedata.com/resource/pubmed/grant/P01 CA095426-10, http://linkedlifedata.com/resource/pubmed/grant/P01 CA95426, http://linkedlifedata.com/resource/pubmed/grant/P30 CA016058-30, http://linkedlifedata.com/resource/pubmed/grant/P30 CA16058, http://linkedlifedata.com/resource/pubmed/grant/R01 CA092704-10, http://linkedlifedata.com/resource/pubmed/grant/R01 CA92704, http://linkedlifedata.com/resource/pubmed/grant/R01 MH051487-05, http://linkedlifedata.com/resource/pubmed/grant/R01 MH51487, http://linkedlifedata.com/resource/pubmed/grant/T32 GM068412, http://linkedlifedata.com/resource/pubmed/grant/T32 GM068412-05
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1090-2163
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
270
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
80-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients.
pubmed:affiliation
Department of Integrated Biomedical Sciences, The Ohio State University, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH 43210, USA.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural