21600017

Source:http://linkedlifedata.com/resource/pubmed/id/21600017

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0023487, umls-concept:C0031727, umls-concept:C0035339, umls-concept:C0162638, umls-concept:C0205263, umls-concept:C1513354, umls-concept:C1879547
pubmed:dateCreated	2011-6-17
pubmed:abstractText	Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, a small-molecule Aurora kinase inhibitor, interferes with mitotic entry and formation of bipolar spindles. Here, we evaluated VX-680 as a potential agent for treatment of all-trans retinoid acid (ATRA)-resistant acute promyelocytic leukemia (APL) in vitro.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101190741
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Annexin A5, http://linkedlifedata.com/resource/pubmed/chemical/Caspases, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Propidium, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Small Molecule Libraries, http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin, http://linkedlifedata.com/resource/pubmed/chemical/VX680, http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase
pubmed:status	MEDLINE
pubmed:issn	1479-5876
pubmed:author	pubmed-author:ChenJia-JieJJ, pubmed-author:HuangShanS, pubmed-author:LiJuanJ, pubmed-author:LinDong-JunDJ, pubmed-author:LiuQuentinQ, pubmed-author:LongZi-JieZJ, pubmed-author:XuDuo-RongDR, pubmed-author:ZouZheng-ZhiZZ
pubmed:issnType	Electronic
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	74
pubmed:meshHeading	pubmed-meshheading:21600017-Annexin A5, pubmed-meshheading:21600017-Apoptosis, pubmed-meshheading:21600017-Caspases, pubmed-meshheading:21600017-Cell Differentiation, pubmed-meshheading:21600017-Cell Line, Tumor, pubmed-meshheading:21600017-Cell Nucleus, pubmed-meshheading:21600017-Cell Proliferation, pubmed-meshheading:21600017-Drug Resistance, Neoplasm, pubmed-meshheading:21600017-Enzyme Activation, pubmed-meshheading:21600017-Humans, pubmed-meshheading:21600017-Leukemia, Promyelocytic, Acute, pubmed-meshheading:21600017-Membrane Potential, Mitochondrial, pubmed-meshheading:21600017-Mitosis, pubmed-meshheading:21600017-Mitotic Spindle Apparatus, pubmed-meshheading:21600017-Piperazines, pubmed-meshheading:21600017-Propidium, pubmed-meshheading:21600017-Protein Kinase Inhibitors, pubmed-meshheading:21600017-Protein-Serine-Threonine Kinases, pubmed-meshheading:21600017-Proto-Oncogene Proteins c-akt, pubmed-meshheading:21600017-Small Molecule Libraries, pubmed-meshheading:21600017-Tretinoin
pubmed:year	2011
pubmed:articleTitle	Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells.
pubmed:affiliation	State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China. xudr@hotmail.com
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't