Source:http://linkedlifedata.com/resource/pubmed/id/21598178
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2011-5-20
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| pubmed:abstractText |
We determined the association between charred meat consumption, cigarette smoking, microsomal epoxide hydrolase (mEH) polymorphisms (rs1051740 and rs2234922), and colorectal adenomas and hyperplastic polyps (HPs) and explored gene-environment interactions. Men and women with colorectal adenomas (n = 519), HPs (n = 691), or concurrently with both types of polyps (n = 227) and polyp-free controls (n = 772) receiving a colonoscopy from December 2004 to September 2007 were recruited. Participants completed telephone interviews and provided buccal cell samples; genotyping of mEH was completed using Taqman assays. We conducted polytomous regression and calculated odd ratios (OR) and 95% confidence intervals. Interactions were evaluated using Wald chi-square tests. Consumption of >3 servings of charred meat per week was associated with distal HPs (OR = 2.0, 1.2-3.4) but not adenomas nor either type of proximal polyp. Heavy cigarette smoking (? 22 pack-years) was associated with an increased risk for colorectal adenomas (OR = 1.7, 95% CI: 1.2-2.4), HPs (OR = 2.4, 95% CI: 1.7-3.3), and both types (OR = 2.8, 95% CI: 1.8-4.3) with the strongest association for distal polyps. There was no association between mEH genotype and colorectal polyps, nor were any statistically significant gene-environment interactions identified. Future investigation of BaP exposure and colorectal neoplasia should analyze whether associations are dependent upon anatomic location.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01 CA 074794,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097325-05,
http://linkedlifedata.com/resource/pubmed/grant/R25 CA094880-09,
http://linkedlifedata.com/resource/pubmed/grant/R25 CA94880,
http://linkedlifedata.com/resource/pubmed/grant/T32 CA009168-34,
http://linkedlifedata.com/resource/pubmed/grant/T32 CA09168-32
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1532-7914
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
63
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
583-92
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| pubmed:dateRevised |
2011-9-26
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| pubmed:meshHeading |
pubmed-meshheading:21598178-Adult,
pubmed-meshheading:21598178-Aged,
pubmed-meshheading:21598178-Animals,
pubmed-meshheading:21598178-Benzo(a)pyrene,
pubmed-meshheading:21598178-Colonic Polyps,
pubmed-meshheading:21598178-Colonoscopy,
pubmed-meshheading:21598178-Colorectal Neoplasms,
pubmed-meshheading:21598178-Cooking,
pubmed-meshheading:21598178-Epoxide Hydrolases,
pubmed-meshheading:21598178-Female,
pubmed-meshheading:21598178-Genotype,
pubmed-meshheading:21598178-Hot Temperature,
pubmed-meshheading:21598178-Humans,
pubmed-meshheading:21598178-Hyperplasia,
pubmed-meshheading:21598178-Logistic Models,
pubmed-meshheading:21598178-Male,
pubmed-meshheading:21598178-Meat,
pubmed-meshheading:21598178-Middle Aged,
pubmed-meshheading:21598178-Multivariate Analysis,
pubmed-meshheading:21598178-Polymorphism, Single Nucleotide,
pubmed-meshheading:21598178-Risk Factors,
pubmed-meshheading:21598178-Smoking,
pubmed-meshheading:21598178-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms.
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| pubmed:affiliation |
Department of Epidemiology, University of Washington, Seattle, Washington, USA. aburnett@fhcrc.org
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|