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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-7-21
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pubmed:abstractText |
Earlier studies have suggested that a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG). Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic controls and confirmed that a spectrum of common and rare lipid-associated variants underlies this heterogeneity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:AnandSonia SSS,
pubmed-author:BanMatthew RMR,
pubmed-author:Dallinga-ThieGeesje MGM,
pubmed-author:ElosuaRobertoR,
pubmed-author:HassellReina GRG,
pubmed-author:HegeleRobert ARA,
pubmed-author:HensonT ATA,
pubmed-author:HuffMurray WMW,
pubmed-author:JohansenChristopher TCT,
pubmed-author:KathiresanSekarS,
pubmed-author:KennedyBrooke ABA,
pubmed-author:LanktreeMatthew BMB,
pubmed-author:MartinsRebecca ARA,
pubmed-author:McIntyreAdam DAD,
pubmed-author:O'DonnellChristopher JCJ,
pubmed-author:SalomaaVeikkoV,
pubmed-author:SchwartzStephen MSM,
pubmed-author:VisserMaartje EME,
pubmed-author:VoightBenjamin FBF,
pubmed-author:WangJianJ,
pubmed-author:YusufSalimS
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1916-26
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pubmed:meshHeading |
pubmed-meshheading:21597005-Adult,
pubmed-meshheading:21597005-Aged,
pubmed-meshheading:21597005-Alleles,
pubmed-meshheading:21597005-Apolipoprotein E2,
pubmed-meshheading:21597005-Case-Control Studies,
pubmed-meshheading:21597005-Cholesterol, HDL,
pubmed-meshheading:21597005-Cholesterol, LDL,
pubmed-meshheading:21597005-Female,
pubmed-meshheading:21597005-Genetic Predisposition to Disease,
pubmed-meshheading:21597005-Genetic Variation,
pubmed-meshheading:21597005-Humans,
pubmed-meshheading:21597005-Hyperlipoproteinemia Type IV,
pubmed-meshheading:21597005-Hypertriglyceridemia,
pubmed-meshheading:21597005-Lipids,
pubmed-meshheading:21597005-Male,
pubmed-meshheading:21597005-Middle Aged,
pubmed-meshheading:21597005-Multifactorial Inheritance,
pubmed-meshheading:21597005-Phenotype,
pubmed-meshheading:21597005-Risk Factors,
pubmed-meshheading:21597005-Triglycerides
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pubmed:year |
2011
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pubmed:articleTitle |
An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.
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pubmed:affiliation |
Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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