Linked Life Data

21596433

Source:http://linkedlifedata.com/resource/pubmed/id/21596433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-6-7
pubmed:abstractText
Bile acids are the toxic end products of hepatic cholesterol metabolism. They are synthesised from early in gestation and excreted via the placenta. The mechanism for transplacental excretion of bile acids is not known. The gene and protein expression of the nuclear receptors responsible for hepatic bile acid metabolism and transport was studied in eight normal and fourteen cholestatic placentas, and in an ex vivo model. The expression of the nuclear receptor FXR and several of it's target genes and of PXR and CAR was found to be very low in both normal and cholestatic placenta.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1532-3102
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
535-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Characterisation of the nuclear receptors FXR, PXR and CAR in normal and cholestatic placenta.
pubmed:affiliation
Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't