Source:http://linkedlifedata.com/resource/pubmed/id/21595536
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-5-20
|
| pubmed:abstractText |
Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder affecting melanocytes in the skin, eyes, inner ear, and meninges. The Epstein-Barr virus and cytomegalovirus (CMV) antigen have been hypothesized as possible triggering factors for the disease. Toll-like receptors (TLRs) play an important role in the induction of defense mechanisms of the innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR9 recognizes unmethylated 2'-deoxyribo (cytidine-phosphate guanosine)(CpG) DNA motifs that are frequently present in viruses and plays a central role in the host defense against viral infection. The aim of this study was to investigate whether TLR9 polymorphisms were associated with VKH in a Japanese population.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1744-5078
|
| pubmed:author |
pubmed-author:HorieYukihiroY,
pubmed-author:InokoHidetoshiH,
pubmed-author:ItoRyutaR,
pubmed-author:KatsuyamaYoshihikoY,
pubmed-author:KitaichiNobuyoshiN,
pubmed-author:MarksP GPG,
pubmed-author:MeguroAkiraA,
pubmed-author:MizukiNobuhisaN,
pubmed-author:NambaKenichiK,
pubmed-author:NishideTadayukiT,
pubmed-author:NomuraEiichiE,
pubmed-author:OhnoShigeakiS,
pubmed-author:UemotoRiyoR
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
202-5
|
| pubmed:dateRevised |
2011-10-30
|
| pubmed:meshHeading |
pubmed-meshheading:21595536-Asian Continental Ancestry Group,
pubmed-meshheading:21595536-Gene Frequency,
pubmed-meshheading:21595536-Genotype,
pubmed-meshheading:21595536-Haplotypes,
pubmed-meshheading:21595536-Humans,
pubmed-meshheading:21595536-Linkage Disequilibrium,
pubmed-meshheading:21595536-Polymorphism, Single Nucleotide,
pubmed-meshheading:21595536-Toll-Like Receptor 9,
pubmed-meshheading:21595536-Uveomeningoencephalitic Syndrome
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Investigation of association between TLR9 gene polymorphisms and VKH in Japanese patients.
|
| pubmed:affiliation |
Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
|
| pubmed:publicationType |
Journal Article
|