Linked Life Data

21592547

Source:http://linkedlifedata.com/resource/pubmed/id/21592547

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-7-18
pubmed:abstractText
Simultaneous independent primary tumors of the female genital tract occur in 1-2% of gynecological cancer patients, 50-70% of which are synchronous tumors of the endometrium and ovary. Guidelines for determining the nature of simultaneously detected tumors, based on surgical and histopathological findings, are often ambiguous and may require further molecular analyses. Such approach is necessary to indicate correct prognosis and hence treatment. We here demonstrate how mitochondrial DNA sequencing may provide a cheap and useful tool to contribute to indisputably recognize the synchronous nature of simultaneously detected endometrial and ovarian carcinomas. We further confirm our findings by means of Comparative Genomic Hybridization array analysis, which strengthens the informative potential of mitochondrial DNA genotyping in diagnosing synchrony.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1095-6859
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
457-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Mitochondrial DNA genotyping reveals synchronous nature of simultaneously detected endometrial and ovarian cancers.
pubmed:affiliation
Dip. di Scienze Ginecologiche, Ostetriche e Pediatriche, U.O. Genetica Medica, Pol. Universitario S.Orsola-Malpighi, 40138, Bologna, Italy.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't