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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-6-6
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pubmed:abstractText |
Elevation of cAMP has been considered to be an important downregulative signal in the production of interleukin-1(IL-1). This study demonstrates that this phenomenon is dependent on the signal used to activate the IL-1 production. The IL-1 beta production of lipopolysaccharide activated human monocytes was readily inhibited by dibutyryl cAMP. This took place without a significant change in the steady-state levels of IL-1 beta mRNA. By contrast, in PMA activated monocytes 100 microM dibutyryl cAMP increased in IL-1 beta production ca. 4-fold. The steady-state levels of IL-1 beta mRNA were also simultaneously increased.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
263
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2158905-Bucladesine,
pubmed-meshheading:2158905-Cells, Cultured,
pubmed-meshheading:2158905-Cyclic AMP,
pubmed-meshheading:2158905-Dinoprostone,
pubmed-meshheading:2158905-Forskolin,
pubmed-meshheading:2158905-Humans,
pubmed-meshheading:2158905-Interleukin-1,
pubmed-meshheading:2158905-Kinetics,
pubmed-meshheading:2158905-Lipopolysaccharides,
pubmed-meshheading:2158905-Monocytes,
pubmed-meshheading:2158905-Tetradecanoylphorbol Acetate
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pubmed:year |
1990
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pubmed:articleTitle |
Modulation of interleukin-1 beta production by cyclic AMP in human monocytes.
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pubmed:affiliation |
Department of Bacteriology and Immunology, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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