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pubmed-article:21587237pubmed:abstractTextNeural circuits display a heightened sensitivity to external stimuli during well-established windows in early postnatal life. After the end of these critical periods, brain plasticity dramatically wanes. The visual system is one of the paradigmatic models for studying experience-dependent plasticity. Here we show that food restriction can be used as a strategy to restore plasticity in the adult visual cortex of rats. A short period of food restriction in adulthood is able both to reinstate ocular dominance plasticity and promote recovery from amblyopia. These effects are accompanied by a reduction of intracortical inhibition without modulation of brain-derived neurotrophic factor expression or extracellular matrix structure. Our results suggest that food restriction could be investigated as a potential way of modulating plasticity.lld:pubmed
pubmed-article:21587237pubmed:languageenglld:pubmed
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pubmed-article:21587237pubmed:authorpubmed-author:MaffeiLambert...lld:pubmed
pubmed-article:21587237pubmed:authorpubmed-author:ViegiAlessand...lld:pubmed
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pubmed-article:21587237pubmed:authorpubmed-author:BaroncelliLau...lld:pubmed
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pubmed-article:21587237pubmed:authorpubmed-author:Maya-Vetencou...lld:pubmed
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pubmed-article:21587237pubmed:year2011lld:pubmed
pubmed-article:21587237pubmed:articleTitleFood restriction enhances visual cortex plasticity in adulthood.lld:pubmed
pubmed-article:21587237pubmed:affiliationInstitute of Neuroscience, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, I-56100 Pisa, Italy.lld:pubmed
pubmed-article:21587237pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21587237pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed