Linked Life Data

21587237

Source:http://linkedlifedata.com/resource/pubmed/id/21587237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-5-18
pubmed:abstractText
Neural circuits display a heightened sensitivity to external stimuli during well-established windows in early postnatal life. After the end of these critical periods, brain plasticity dramatically wanes. The visual system is one of the paradigmatic models for studying experience-dependent plasticity. Here we show that food restriction can be used as a strategy to restore plasticity in the adult visual cortex of rats. A short period of food restriction in adulthood is able both to reinstate ocular dominance plasticity and promote recovery from amblyopia. These effects are accompanied by a reduction of intracortical inhibition without modulation of brain-derived neurotrophic factor expression or extracellular matrix structure. Our results suggest that food restriction could be investigated as a potential way of modulating plasticity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
2041-1723
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
320
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Food restriction enhances visual cortex plasticity in adulthood.
pubmed:affiliation
Institute of Neuroscience, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, I-56100 Pisa, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't