Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-5-25
|
| pubmed:abstractText |
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds on the specific patterns of age-dependent I-compound DNA adducts in the liver of male and female Sprague-Dawley rats were determined by the 32P-postlabeling assay. In female rats, TCDD causes a dose-dependent decrease of several individual and total hepatic I-compound levels after administration of 1 and 5 micrograms/kg per week for 4 weeks. In contrast, no such effects were observed in male Sprague-Dawley rats treated with the 5 micrograms/kg dose level of TCDD. The relative effects of TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PCDD) and 1,2,4,7,8-PCDD on hepatic I-compound levels in the susceptible female Sprague-Dawley rats were determined using a dose of 5 micrograms/kg per week for 4 weeks. The two compounds which are substituted in all four lateral positions, namely TCDD and 1,2,3,7,8-PCDD, caused a significant decrease in hepatic I-compound levels, whereas 1,2,4,7,8-PCDD which is substituted in only three lateral positions was inactive. The structure-activity relationships observed for the effects of these compounds on hepatic I-compounds correlated with their corresponding structure-Ah receptor binding and structure-toxicity relationships. The results are therefore consistent with a role for the Ah receptor in the TCDD-mediated reduction in hepatic I-compound levels in female Sprague-Dawley rats. These results and data from previous studies demonstrate a correlation between the susceptibility of an organ/species to the carcinogenic effects of TCDD and the reduction of I-compound levels. The significance of this correlation in the development of TCDD-induced carcinogenesis has not been delineated.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Aryl Hydrocarbon,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Single-Strand Specific DNA and RNA...,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrachlorodibenzodioxin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0041-008X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
271-80
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2158676-Age Factors,
pubmed-meshheading:2158676-Animals,
pubmed-meshheading:2158676-Carcinogens,
pubmed-meshheading:2158676-Chromatography, Thin Layer,
pubmed-meshheading:2158676-DNA,
pubmed-meshheading:2158676-Dioxins,
pubmed-meshheading:2158676-Female,
pubmed-meshheading:2158676-Liver,
pubmed-meshheading:2158676-Liver Neoplasms,
pubmed-meshheading:2158676-Male,
pubmed-meshheading:2158676-Rats,
pubmed-meshheading:2158676-Rats, Inbred Strains,
pubmed-meshheading:2158676-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:2158676-Receptors, Drug,
pubmed-meshheading:2158676-Sex Factors,
pubmed-meshheading:2158676-Single-Strand Specific DNA and RNA Endonucleases,
pubmed-meshheading:2158676-Structure-Activity Relationship,
pubmed-meshheading:2158676-Tetrachlorodibenzodioxin
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships.
|
| pubmed:affiliation |
Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|