Linked Life Data

2158016

Source:http://linkedlifedata.com/resource/pubmed/id/2158016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-5-24
pubmed:abstractText
Tubulization of sectioned rat sciatic nerves was used to evaluate the effect of dibutyryl cyclic adenosine monophosphate (db-cAMP), a fragment of the adrenocorticotrophic hormone (ACTH(4-10] and gangliosides on the regrowth of injured nerve processes. Four weeks post-operative, the number of myelinated fibers was counted at different levels of the lesioned sciatic nerves and the endoneurium surface of the bridging structure in the tube was measured. Animals treated with gangliosides and db-AMPc showed statistically significant differences compared to vehicle treated rats. The gangliosides have shown a beneficial effect but db-cAMP diminished the number of myelinated fibers. In this case, an implication of Schwann cell mitosis and migration is discussed. In spite of better results obtained in ACTH(4-10)-treated animals compared to controls, the differences did not attain a statistically significant level. These experiments confirm the beneficial effect of gangliosides on peripheral nerve regeneration and reveal a negative effect of db-cAMP in the regeneration chamber model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
180-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of dibutyryl cyclic adenosine monophosphate, ACTH(4-10) and gangliosides on nerve fiber regeneration after rat sciatic nerve tubulization.
pubmed:affiliation
Université Catholique de Louvain, Laboratoire de Biologie Cellulaire, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't