Linked Life Data

21576471

Source:http://linkedlifedata.com/resource/pubmed/id/21576471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2011-6-1
pubmed:abstractText
MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-?B activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts, showing that they are true malignancies. The animals also exhibit chronic myeloproliferation in their bone marrow. Spleen and marrow cells show increased transcription of NF-?B-regulated genes and tumors have higher nuclear p65. Genetic ablation of NF-?B p50 suppresses the myeloproliferation, showing that dysregulation of NF-?B is responsible for the myeloproliferative disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
31
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9184-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies.
pubmed:affiliation
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural