| pubmed-article:21575863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21575863 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:21575863 | lifeskim:mentions | umls-concept:C0596263 | lld:lifeskim |
| pubmed-article:21575863 | lifeskim:mentions | umls-concept:C1335280 | lld:lifeskim |
| pubmed-article:21575863 | lifeskim:mentions | umls-concept:C1325410 | lld:lifeskim |
| pubmed-article:21575863 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:21575863 | lifeskim:mentions | umls-concept:C2697585 | lld:lifeskim |
| pubmed-article:21575863 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21575863 | pubmed:dateCreated | 2011-5-17 | lld:pubmed |
| pubmed-article:21575863 | pubmed:abstractText | The human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor-suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes. Decreased Shp2 expression was detected in a subfraction of human HCC specimens. Thus, in contrast to the leukemogenic effect of dominant-active mutants, Ptpn11/Shp2 has a tumor-suppressor function in liver. | lld:pubmed |
| pubmed-article:21575863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21575863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21575863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21575863 | pubmed:month | May | lld:pubmed |
| pubmed-article:21575863 | pubmed:issn | 1878-3686 | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:TaoHanH | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:WangHongyangH | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:VarkiNissi... | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:PoliValeriaV | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:FengGen-Sheng... | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:DingJinJ | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:Bailly-Maitre... | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:PrincenFreder... | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:Bard-ChapeauE... | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:LiShuangweiS | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:ZhangSharon... | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:ZhuHelen HHH | lld:pubmed |
| pubmed-article:21575863 | pubmed:author | pubmed-author:FangDiane DDD | lld:pubmed |
| pubmed-article:21575863 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21575863 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21575863 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:21575863 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:21575863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21575863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21575863 | pubmed:pagination | 629-39 | lld:pubmed |
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| pubmed-article:21575863 | pubmed:meshHeading | pubmed-meshheading:21575863... | lld:pubmed |
| pubmed-article:21575863 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21575863 | pubmed:articleTitle | Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. | lld:pubmed |
| pubmed-article:21575863 | pubmed:affiliation | Department of Pathology, University of California San Diego, La Jolla, CA 92093-0864, USA. | lld:pubmed |
| pubmed-article:21575863 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21575863 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21575863 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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