|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2011-5-17
|
|
pubmed:abstractText |
The human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor-suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes. Decreased Shp2 expression was detected in a subfraction of human HCC specimens. Thus, in contrast to the leukemogenic effect of dominant-active mutants, Ptpn11/Shp2 has a tumor-suppressor function in liver.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylnitrosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1878-3686
|
|
pubmed:author |
pubmed-author:Bailly-MaitreBeatriceB,
pubmed-author:Bard-ChapeauEmilie AEA,
pubmed-author:DingJinJ,
pubmed-author:FangDiane DDD,
pubmed-author:FengGen-ShengGS,
pubmed-author:LiShuangweiS,
pubmed-author:PoliValeriaV,
pubmed-author:PrincenFredericF,
pubmed-author:TaoHanH,
pubmed-author:VarkiNissi MNM,
pubmed-author:WangHongyangH,
pubmed-author:ZhangSharon SSS,
pubmed-author:ZhuHelen HHH
|
|
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
17
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
629-39
|
|
pubmed:meshHeading |
pubmed-meshheading:21575863-Adenoma, Liver Cell,
pubmed-meshheading:21575863-Animals,
pubmed-meshheading:21575863-Carcinoma, Hepatocellular,
pubmed-meshheading:21575863-Cytokines,
pubmed-meshheading:21575863-Diethylnitrosamine,
pubmed-meshheading:21575863-Gene Expression Regulation,
pubmed-meshheading:21575863-Hepatitis,
pubmed-meshheading:21575863-Humans,
pubmed-meshheading:21575863-Hyperplasia,
pubmed-meshheading:21575863-Inflammation Mediators,
pubmed-meshheading:21575863-Interleukin-6,
pubmed-meshheading:21575863-Lipopolysaccharides,
pubmed-meshheading:21575863-Liver,
pubmed-meshheading:21575863-Liver Neoplasms,
pubmed-meshheading:21575863-Liver Regeneration,
pubmed-meshheading:21575863-Male,
pubmed-meshheading:21575863-Mice,
pubmed-meshheading:21575863-Mice, Inbred C57BL,
pubmed-meshheading:21575863-Mice, Knockout,
pubmed-meshheading:21575863-Necrosis,
pubmed-meshheading:21575863-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:21575863-STAT3 Transcription Factor,
pubmed-meshheading:21575863-Signal Transduction,
pubmed-meshheading:21575863-Time Factors,
pubmed-meshheading:21575863-Tumor Suppressor Proteins
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
|
|
pubmed:affiliation |
Department of Pathology, University of California San Diego, La Jolla, CA 92093-0864, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
