Linked Life Data

2157468

Source:http://linkedlifedata.com/resource/pubmed/id/2157468

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-5-14
pubmed:abstractText
Angiotensin II (Ang II) exerts a variety of actions through specific receptor binding in the kidney. These include modulation of renal hemodynamics, glomerular filtration rate (GFR), and tubular reabsorption. Quantitative in vitro autoradiography was used to localize the Ang II receptors and angiotensin converting enzyme (ACE) in rat, rabbit, and human kidney. We incubated 20 microns cryostat sections of kidney with either 125I-[Sar1]Ang II or 125I-[Sar1,Ile8]Ang II for Ang II binding or with 125I-351A for ACE localization. The resulting autoradiographs were analyzed by computerized densitometry. A high density of Ang II binding was found over glomeruli and vasa recta bundles in all species examined. The interbundle area of the outer medulla was associated with low to moderate binding of Ang II. Moderate binding of Ang II was observed over proximal convoluted tubules in the outer cortex of rat kidney. ACE was predominantly distributed in proximal convoluted tubules in all species. These studies reveal multiple sites where Ang II could modulate renal function by acting on the renal vasculature, glomeruli, vasa recta bundles, and proximal tubular sites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0895-7061
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
250-5
pubmed:dateRevised
2009-2-24
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Angiotensin II receptors in the kidney. Localization and physiological significance.
pubmed:affiliation
Department of Medicine, Austin Hospital, Heidelberg, Victoria.
pubmed:publicationType
Journal Article