Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-5-3
pubmed:abstractText
Previous research has shown that estradiol administered either peripherally or directly into the striatum potentiates the dorsal immobility response (DIR) in ovariectomized female rats. Male rats are even more responsive than females to intrastriatal estradiol, and furthermore respond to the effects of catecholestrogens while females do not. In order to determine whether the heightened effects of estrogens in males are due to conversion to catecholestrogens, castrated male rats were given bilateral intrastriatal implants of moxestrol, which cannot be readily converted to a catecholestrogen, and diethylstilbestrol, which can. To determine whether the effects of intrastriatal estradiol in male rats might be related to the effects of androgens on the striatum, castrated male rats were given bilateral intrastriatal implants of testosterone, which can be aromatized to estrogen, and 5 alpha-dihydrotestosterone, which cannot. The effects of each of the hormones tested were measured against those of cholesterol (an inactive control substance) and 17 beta-estradiol. In each case the DIR was measured four hours after the hormone implant. Both synthetic estrogens and 17 beta-estradiol significantly potentiated the DIR, while neither of the androgens had an effect. Thus, the effects of estradiol, synthetic estrogens and catecholestrogens on the male striatum appear to be due to the estrogenic properties of these hormones.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of intrastriatal hormones on the dorsal immobility response in male rats.
pubmed:affiliation
Psychology Department, University of Florida, Gainesville 32611.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.