| pubmed-article:21571370 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C0053932 | lld:lifeskim |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21571370 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21571370 | pubmed:issue | 12-13 | lld:pubmed |
| pubmed-article:21571370 | pubmed:dateCreated | 2011-6-6 | lld:pubmed |
| pubmed-article:21571370 | pubmed:abstractText | Interleukin 1? (IL-1?) is a pro-inflammatory cytokine secreted by activated macrophages and monocytes. Previously, we have reported that bone morphogenetic protein-6 (BMP-6) induces inducible nitric oxide synthase (iNOS) expression via IL-1? in macrophages. In the present study, we demonstrate that BMP-6 increases IL-1? expression in macrophages via the receptors ALK3 and BMPRII as well as the downstream signaling protein Smad1. Surprisingly though, inhibition of the ERK and JNK non-Smad pathways also completely blocked the induction of IL-1? by BMP-6 in macrophages. Further analysis revealed that a physical interaction between the transcription factor PU.1 and Smad 1 is necessary for the upregulation of IL-1? expression by BMP-6 in macrophages. Taken together, these results demonstrate that BMP-6-induced IL-1? expression in macrophages is mediated via a cross-talk between the Smad and the non-Smad pathways through Smad1 and PU.1. | lld:pubmed |
| pubmed-article:21571370 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21571370 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21571370 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21571370 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21571370 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21571370 | pubmed:issn | 1872-9142 | lld:pubmed |
| pubmed-article:21571370 | pubmed:author | pubmed-author:LeeJae-HoJH | lld:pubmed |
| pubmed-article:21571370 | pubmed:author | pubmed-author:KimIsaac YiIY | lld:pubmed |
| pubmed-article:21571370 | pubmed:author | pubmed-author:LeeGeun... | lld:pubmed |
| pubmed-article:21571370 | pubmed:author | pubmed-author:KimWun-JaeWJ | lld:pubmed |
| pubmed-article:21571370 | pubmed:author | pubmed-author:JungYeon... | lld:pubmed |
| pubmed-article:21571370 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21571370 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21571370 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:21571370 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21571370 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21571370 | pubmed:pagination | 1540-7 | lld:pubmed |
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| pubmed-article:21571370 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21571370 | pubmed:articleTitle | Bone morphogenetic protein 6-induced interleukin-1? expression in macrophages requires PU.1/Smad1 interaction. | lld:pubmed |
| pubmed-article:21571370 | pubmed:affiliation | Section of Urologic Oncology and the Dean and Betty Gallo Prostate Cancer Center, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street #4560, New Brunswick, NJ 08903, United States. | lld:pubmed |
| pubmed-article:21571370 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21571370 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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