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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12-13
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pubmed:dateCreated |
2011-6-6
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pubmed:abstractText |
Interleukin 1? (IL-1?) is a pro-inflammatory cytokine secreted by activated macrophages and monocytes. Previously, we have reported that bone morphogenetic protein-6 (BMP-6) induces inducible nitric oxide synthase (iNOS) expression via IL-1? in macrophages. In the present study, we demonstrate that BMP-6 increases IL-1? expression in macrophages via the receptors ALK3 and BMPRII as well as the downstream signaling protein Smad1. Surprisingly though, inhibition of the ERK and JNK non-Smad pathways also completely blocked the induction of IL-1? by BMP-6 in macrophages. Further analysis revealed that a physical interaction between the transcription factor PU.1 and Smad 1 is necessary for the upregulation of IL-1? expression by BMP-6 in macrophages. Taken together, these results demonstrate that BMP-6-induced IL-1? expression in macrophages is mediated via a cross-talk between the Smad and the non-Smad pathways through Smad1 and PU.1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bmpr1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bmpr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 6,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/proto-oncogene protein Spi-1
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1872-9142
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1540-7
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pubmed:meshHeading |
pubmed-meshheading:21571370-Animals,
pubmed-meshheading:21571370-Bone Morphogenetic Protein 6,
pubmed-meshheading:21571370-Bone Morphogenetic Protein Receptors, Type I,
pubmed-meshheading:21571370-Bone Morphogenetic Protein Receptors, Type II,
pubmed-meshheading:21571370-Cells, Cultured,
pubmed-meshheading:21571370-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:21571370-Fluorescent Antibody Technique,
pubmed-meshheading:21571370-Immunoblotting,
pubmed-meshheading:21571370-Immunoprecipitation,
pubmed-meshheading:21571370-Interleukin-1beta,
pubmed-meshheading:21571370-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:21571370-Macrophages,
pubmed-meshheading:21571370-Mice,
pubmed-meshheading:21571370-Nitric Oxide Synthase Type II,
pubmed-meshheading:21571370-Proto-Oncogene Proteins,
pubmed-meshheading:21571370-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21571370-Signal Transduction,
pubmed-meshheading:21571370-Smad1 Protein,
pubmed-meshheading:21571370-Trans-Activators
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pubmed:year |
2011
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pubmed:articleTitle |
Bone morphogenetic protein 6-induced interleukin-1? expression in macrophages requires PU.1/Smad1 interaction.
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pubmed:affiliation |
Section of Urologic Oncology and the Dean and Betty Gallo Prostate Cancer Center, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street #4560, New Brunswick, NJ 08903, United States.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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