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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-6-1
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pubmed:abstractText |
Despite lots of research efforts, the pathology of head and neck cancer remains elusive. Accumulating evidence suggests that the innate and adaptive immunity plays an important role in HNSCC (Head and Neck Squamous Cell Carcinoma) development. Recently, a new T helper cell subset additional to the classical Th1 and Th2 cells was identified called Th17 cells, due to their secretion of IL-17. However, Th17 cells also produce additional proinflammatory cytokines and many other cytokines are involved in their differentiation and expansion. It was shown that Th17 cells play a prominent role in host defense but are also associated with the development of autoimmune diseases. The role of Th17 cells in cancer pathogenesis remains nebulous.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-2163
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
269
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-7
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pubmed:meshHeading |
pubmed-meshheading:21570678-Aged,
pubmed-meshheading:21570678-Brefeldin A,
pubmed-meshheading:21570678-Carcinoma, Squamous Cell,
pubmed-meshheading:21570678-Culture Media, Conditioned,
pubmed-meshheading:21570678-Head and Neck Neoplasms,
pubmed-meshheading:21570678-Humans,
pubmed-meshheading:21570678-Ionomycin,
pubmed-meshheading:21570678-Leukocytes, Mononuclear,
pubmed-meshheading:21570678-Lymph Nodes,
pubmed-meshheading:21570678-Lymphocyte Activation,
pubmed-meshheading:21570678-Middle Aged,
pubmed-meshheading:21570678-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:21570678-Neoplasm Metastasis,
pubmed-meshheading:21570678-Tetradecanoylphorbol Acetate,
pubmed-meshheading:21570678-Th17 Cells
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pubmed:year |
2011
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pubmed:articleTitle |
The number of CD161 positive Th17 cells are decreased in head and neck cancer patients.
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pubmed:affiliation |
Department for Otorhinolaryngology and Plastic Surgery, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
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pubmed:publicationType |
Journal Article
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