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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-7-18
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pubmed:abstractText |
About 10% of cutaneous malignant melanomas (CMM) occur in individuals with a family history of melanoma. In 20% to 40% of melanoma families germline mutations in CDKN2A are detected. Knowledge of the clinicohistologic characteristics of melanomas and patients from these families is important for optimization of management strategies, and may shed more light on the complex interplay of genetic and environmental factors in the pathogenesis of melanoma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1097-6787
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-8
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pubmed:meshHeading |
pubmed-meshheading:21570156-Adult,
pubmed-meshheading:21570156-Age Distribution,
pubmed-meshheading:21570156-Age of Onset,
pubmed-meshheading:21570156-Aged,
pubmed-meshheading:21570156-Biopsy, Needle,
pubmed-meshheading:21570156-Case-Control Studies,
pubmed-meshheading:21570156-Databases, Factual,
pubmed-meshheading:21570156-Female,
pubmed-meshheading:21570156-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21570156-Genes, p16,
pubmed-meshheading:21570156-Genetic Predisposition to Disease,
pubmed-meshheading:21570156-Germ-Line Mutation,
pubmed-meshheading:21570156-Humans,
pubmed-meshheading:21570156-Immunohistochemistry,
pubmed-meshheading:21570156-Incidence,
pubmed-meshheading:21570156-Male,
pubmed-meshheading:21570156-Melanoma,
pubmed-meshheading:21570156-Middle Aged,
pubmed-meshheading:21570156-Neoplasm Staging,
pubmed-meshheading:21570156-Pedigree,
pubmed-meshheading:21570156-Prognosis,
pubmed-meshheading:21570156-Reference Values,
pubmed-meshheading:21570156-Registries,
pubmed-meshheading:21570156-Risk Assessment,
pubmed-meshheading:21570156-Sex Distribution,
pubmed-meshheading:21570156-Skin Neoplasms,
pubmed-meshheading:21570156-Survival Analysis
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pubmed:year |
2011
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pubmed:articleTitle |
Clinical and histologic characteristics of malignant melanoma in families with a germline mutation in CDKN2A.
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pubmed:affiliation |
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. j.i.van_der_rhee@lumc.nl
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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