21569619

Source:http://linkedlifedata.com/resource/pubmed/id/21569619

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005117, umls-concept:C0022173, umls-concept:C0870883, umls-concept:C1510411
pubmed:dateCreated	2011-5-30
pubmed:abstractText	Berberine (BBR) is a drug with multiple effects on cellular energy metabolism. The present study explored answers to the question of which CYP450 (Cytochrome P450) isoenzymes execute the phase-I transformation for BBR, and what are the bioactivities of its metabolites on energy pathways.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-10220483, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-12093814, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-12642457, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-15181000, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-15198967, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-15199031, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-15258162, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-15531889, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-16100034, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-16162505, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-16352597, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-16873688, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-16954191, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-16956957, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-1730627, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-17311915, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-17531424, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-17540336, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-17971514, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-18337056, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-18397984, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-18635745, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-18640378, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-18703644, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-18723485, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-18818195, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-19059538, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-19090767, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-19800084, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-20673726, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-9013547, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-9492382, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-9860924, http://linkedlifedata.com/resource/pubmed/commentcorrection/21569619-9952310
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101190741
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Berberine, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL, http://linkedlifedata.com/resource/pubmed/chemical/berberrubine, http://linkedlifedata.com/resource/pubmed/chemical/demethyleneberberine, http://linkedlifedata.com/resource/pubmed/chemical/jatrorrhizine, http://linkedlifedata.com/resource/pubmed/chemical/thalifendine
pubmed:status	MEDLINE
pubmed:issn	1479-5876
pubmed:author	pubmed-author:DiemEE, pubmed-author:IOVAAA, pubmed-author:JiangJian-DongJD, pubmed-author:KongWei-JiaWJ, pubmed-author:LiYiY, pubmed-author:LiYing-HongYH, pubmed-author:LiZhuo-RongZR, pubmed-author:SongDan-QingDQ, pubmed-author:WangYan-XiangYX, pubmed-author:WangYue-MingYM, pubmed-author:YangPengP
pubmed:issnType	Electronic
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	62
pubmed:meshHeading	pubmed-meshheading:21569619-AMP-Activated Protein Kinases, pubmed-meshheading:21569619-Animals, pubmed-meshheading:21569619-Berberine, pubmed-meshheading:21569619-Biotransformation, pubmed-meshheading:21569619-Cytochrome P-450 Enzyme System, pubmed-meshheading:21569619-Hep G2 Cells, pubmed-meshheading:21569619-Humans, pubmed-meshheading:21569619-Isoenzymes, pubmed-meshheading:21569619-Liver, pubmed-meshheading:21569619-Male, pubmed-meshheading:21569619-Metabolic Detoxication, Phase I, pubmed-meshheading:21569619-Rats, pubmed-meshheading:21569619-Rats, Wistar, pubmed-meshheading:21569619-Receptor, Insulin, pubmed-meshheading:21569619-Receptors, LDL
pubmed:year	2011
pubmed:articleTitle	Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.
pubmed:affiliation	Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't