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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-6-15
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pubmed:abstractText |
Genomic aberrations can be used to determine cancer diagnosis and prognosis. Clinically relevant novel aberrations can be discovered using high-throughput assays such as Single Nucleotide Polymorphism (SNP) arrays and next-generation sequencing, which typically provide aggregate signals of many cells at once. However, heterogeneity of tumor subclones dramatically complicates the task of detecting aberrations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-10767636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-15355426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-16489013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-16799556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-16899659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-17189563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-17921354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-17943122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-18723673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-18765822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-19039135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-19261174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-19505943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-19581427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-19737800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-19837654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-19903760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-20052272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-20164920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-20174472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-20179022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-20228799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-20364137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-20461076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21569352-9205089
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2164
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
230
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pubmed:meshHeading |
pubmed-meshheading:21569352-Alleles,
pubmed-meshheading:21569352-Cell Line, Tumor,
pubmed-meshheading:21569352-Computational Biology,
pubmed-meshheading:21569352-DNA Copy Number Variations,
pubmed-meshheading:21569352-Gene Dosage,
pubmed-meshheading:21569352-Genotype,
pubmed-meshheading:21569352-High-Throughput Nucleotide Sequencing,
pubmed-meshheading:21569352-Humans,
pubmed-meshheading:21569352-Neoplasms,
pubmed-meshheading:21569352-Reproducibility of Results,
pubmed-meshheading:21569352-Tumor Markers, Biological
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pubmed:year |
2011
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pubmed:articleTitle |
Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies.
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pubmed:affiliation |
Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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