Linked Life Data

21569025

Source:http://linkedlifedata.com/resource/pubmed/id/21569025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-7-6
pubmed:abstractText
We aimed to test the efficacy of ketogenic diet (KD) in patients with Dravet syndrome (DS) not satisfactorily controlled by antiepileptic drugs (AEDs). We included prospectively 15 DS patients aged >3 years with partial response to AEDs including stiripentol. All patients had a seizure diary and clinical examination with Conners and Achenbach scales before KD, at 1 month following onset and every 3 months thereafter. At 1 month, 10 patients (66%) had a decrease of seizure frequency ?75%. Efficacy was maintained in eight responders at 3 and 6 months and in six responders at 9 months. Five patients (33%) remained on KD over 12 months, and one was seizure-free. In addition to efficacy on seizure frequency, KD was beneficial on behavior disturbances including hyperactivity. This effect was reported in all responders and in a few nonresponders. KD might have a double effect, on seizure control and on hyperactivity and behavior disturbances in patients with DS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1528-1167
pubmed:author
pubmed:copyrightInfo
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
pubmed:issnType
Electronic
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e54-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: a prospective pilot study.
pubmed:affiliation
Department of Neuropediatrics, National Referral Center for Rare Epilepsies, Necker-Enfants Malades Hospital, 149 rue de Sévres, Paris, France. rimanabbout@yahoo.com
pubmed:publicationType
Journal Article, Clinical Trial