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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-7-8
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pubmed:abstractText |
TNF-? plays important roles in the pathogenesis of type 1 and type 2 diabetes mellitus. In light of this, we examined the involvement of a pro-apoptotic gene, BBC3 (also known as PUMA), in TNF-?-mediated beta cell dysfunction and destruction in human islets.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1432-0428
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2056-66
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pubmed:meshHeading |
pubmed-meshheading:21567299-Adult,
pubmed-meshheading:21567299-Aged,
pubmed-meshheading:21567299-Animals,
pubmed-meshheading:21567299-Apoptosis Regulatory Proteins,
pubmed-meshheading:21567299-Blotting, Western,
pubmed-meshheading:21567299-Cell Death,
pubmed-meshheading:21567299-Cells, Cultured,
pubmed-meshheading:21567299-Female,
pubmed-meshheading:21567299-Flow Cytometry,
pubmed-meshheading:21567299-Humans,
pubmed-meshheading:21567299-Immunohistochemistry,
pubmed-meshheading:21567299-Insulin-Secreting Cells,
pubmed-meshheading:21567299-Interferon-gamma,
pubmed-meshheading:21567299-Interleukin-8,
pubmed-meshheading:21567299-Islets of Langerhans,
pubmed-meshheading:21567299-Male,
pubmed-meshheading:21567299-Mice,
pubmed-meshheading:21567299-Mice, Inbred NOD,
pubmed-meshheading:21567299-Mice, SCID,
pubmed-meshheading:21567299-Middle Aged,
pubmed-meshheading:21567299-Proto-Oncogene Proteins,
pubmed-meshheading:21567299-Tumor Necrosis Factor-alpha,
pubmed-meshheading:21567299-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-?-induced islet damage in humans.
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pubmed:affiliation |
Beckman Research Institute of the City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA. komori@coh.org
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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