Source:http://linkedlifedata.com/resource/pubmed/id/21566519
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2011-5-16
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pubmed:abstractText |
The distinction of malignant mesothelioma from reactive mesothelial proliferation remains to be a major challenge for surgical pathologists. In this study, we investigated whether insulin-like growth factor II messenger ribonucleic acid-binding protein 3 (IMP3), an oncofetal protein, can be used as a biomarker to distinguish between malignant and reactive mesothelial cells. A total of 109 cases (mesothelioma, n=45; reactive mesothelial proliferation, n=64) were examined by immunohistochemistry for IMP3 expression. IMP3 showed strong cytoplasmic staining in 33 of 45 (73%) mesothelioma cases. In contrast, the expression of IMP3 was undetectable in all (64 cases) benign reactive mesothelial proliferations. Among the IMP3-positive mesotheliomas, 27 (82%) exhibited diffuse IMP3 expression. The vast majority of IMP3-positive subtypes of mesotheliomas showed IMP3 expression in >50% of malignant cells, as this diffuse staining pattern occurred in 17 (81%) cases of epithelial, 4 (100%) cases of sarcomatoid, and 6 (75%) cases of mixed types of mesothelioma. In addition, 2 cases, which were initially diagnosed as atypical mesothelial proliferations and later confirmed to be mesotheliomas, showed diffuse IMP3 expression. Our findings suggest that IMP3 is a new positive biomarker for malignant mesothelioma. IMP3 immunohistochemical staining can be used as an adjunct tool in the distinction of malignant mesothelioma from reactive mesothelial proliferations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1532-0979
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
878-82
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pubmed:meshHeading |
pubmed-meshheading:21566519-Cell Proliferation,
pubmed-meshheading:21566519-Diagnosis, Differential,
pubmed-meshheading:21566519-Epithelium,
pubmed-meshheading:21566519-Humans,
pubmed-meshheading:21566519-Hyperplasia,
pubmed-meshheading:21566519-Mesothelioma,
pubmed-meshheading:21566519-Peritoneal Neoplasms,
pubmed-meshheading:21566519-Peritoneum,
pubmed-meshheading:21566519-Pleura,
pubmed-meshheading:21566519-Pleural Neoplasms,
pubmed-meshheading:21566519-RNA-Binding Proteins,
pubmed-meshheading:21566519-Tumor Markers, Biological
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pubmed:year |
2011
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pubmed:articleTitle |
Oncofetal protein IMP3, a new diagnostic biomarker to distinguish malignant mesothelioma from reactive mesothelial proliferation.
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pubmed:affiliation |
Department of Pathology, University of Massachusetts Medical Center, One Innovation Drive, Worcester, MA 01605, USA.
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pubmed:publicationType |
Journal Article
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