rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-5-16
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pubmed:abstractText |
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly aggressive brain tumors of early childhood poorly responding to therapy. The majority of cases show inactivation of SMARCB1 (INI1, hSNF5, BAF47), a core member of the adenosine triphosphate (ATP)-dependent SWI/SNF chromatin-remodeling complex. We here report the case of a supratentorial AT/RT in a 9-month-old boy, which showed retained SMARCB1 staining on immunohistochemistry and lacked genetic alterations of SMARCB1. Instead, the tumor showed loss of protein expression of another SWI/SNF chromatin-remodeling complex member, the ATPase subunit SMARCA4 (BRG1) due to a homozygous SMARCA4 mutation [c.2032C>T (p.Q678X)]. Our findings highlight the role of SMARCA4 in the pathogenesis of SMARCB1-positive AT/RT and the usefulness of antibodies directed against SMARCA4 in this diagnostic setting.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Codon, Nonsense,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1532-0979
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pubmed:author |
pubmed-author:FrühwaldMichael CMC,
pubmed-author:GeskStefanS,
pubmed-author:GiangasperoFeliceF,
pubmed-author:GianniniCaterinaC,
pubmed-author:HasselblattMartinM,
pubmed-author:JudkinsAlexander RAR,
pubmed-author:ObserTobiasT,
pubmed-author:OyenFlorianF,
pubmed-author:PaulusWernerW,
pubmed-author:RossiSabrinaS,
pubmed-author:SchneppenheimReinhardR,
pubmed-author:SiebertReinerR,
pubmed-author:ViscardiElisabettaE
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
933-5
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pubmed:meshHeading |
pubmed-meshheading:21566516-Brain Neoplasms,
pubmed-meshheading:21566516-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:21566516-Codon, Nonsense,
pubmed-meshheading:21566516-Combined Modality Therapy,
pubmed-meshheading:21566516-DNA Helicases,
pubmed-meshheading:21566516-DNA-Binding Proteins,
pubmed-meshheading:21566516-Fatal Outcome,
pubmed-meshheading:21566516-Gene Silencing,
pubmed-meshheading:21566516-Humans,
pubmed-meshheading:21566516-Infant,
pubmed-meshheading:21566516-Male,
pubmed-meshheading:21566516-Nuclear Proteins,
pubmed-meshheading:21566516-Rhabdoid Tumor,
pubmed-meshheading:21566516-Teratoma,
pubmed-meshheading:21566516-Transcription Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression.
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pubmed:affiliation |
Institute of Neuropathology, University Hospital Münster, Domagkstrasse 19, Münster, Germany. hasselblatt@uni-muenster.de
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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