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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2011-7-7
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pubmed:abstractText |
The type I Melanoma Antigen GEnes (MAGEs) are commonly expressed in cancers, fueling speculation that they may be therapeutic targets with oncogenic potential. They form complexes with RING domain proteins that have E3 ubiquitin ligase activity and promote p53 degradation. MAGE-A3 was detected in tumor specimens from patients with multiple myeloma and its expression correlated with higher frequencies of Ki-67(+) malignant cells. In this report, we examine the mechanistic role of MAGE-A in promoting survival of proliferating multiple myeloma cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AndradeValéria C CVC,
pubmed-author:BhardwajNinaN,
pubmed-author:Chen-KiangSelinaS,
pubmed-author:ChoHearn JayHJ,
pubmed-author:ColemanMortonM,
pubmed-author:DabrowskiAniaA,
pubmed-author:DilibertoMaurizioM,
pubmed-author:HuangXiangaoX,
pubmed-author:JayabalanDavid SDS,
pubmed-author:JungbluthAchim AAA,
pubmed-author:MaiAnjaA,
pubmed-author:NardielloTriciaT,
pubmed-author:NiesvizkyRubenR,
pubmed-author:OldLloyd JLJ,
pubmed-author:PearseRogerR,
pubmed-author:ScottJ PJPJr,
pubmed-author:WasserstrumRebeccaR
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4309-19
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pubmed:meshHeading |
pubmed-meshheading:21565982-Antigens, Neoplasm,
pubmed-meshheading:21565982-Apoptosis,
pubmed-meshheading:21565982-Cell Cycle,
pubmed-meshheading:21565982-Cell Line, Tumor,
pubmed-meshheading:21565982-Cell Proliferation,
pubmed-meshheading:21565982-Disease Progression,
pubmed-meshheading:21565982-Female,
pubmed-meshheading:21565982-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21565982-Gene Silencing,
pubmed-meshheading:21565982-Humans,
pubmed-meshheading:21565982-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:21565982-Male,
pubmed-meshheading:21565982-Middle Aged,
pubmed-meshheading:21565982-Multiple Myeloma,
pubmed-meshheading:21565982-Neoplasm Proteins,
pubmed-meshheading:21565982-Signal Transduction,
pubmed-meshheading:21565982-Tumor Suppressor Protein p53,
pubmed-meshheading:21565982-bcl-2-Associated X Protein
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pubmed:year |
2011
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pubmed:articleTitle |
MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin.
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pubmed:affiliation |
New York University Cancer Institute, New York University School of Medicine, New York, New York, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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