Linked Life Data

2156366

Source:http://linkedlifedata.com/resource/pubmed/id/2156366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1990-4-24
pubmed:abstractText
The mode of action of methylxanthines and benzodiazepines are not yet fully elucidated. Interaction with antagonizing effect occurs between these two preparations, probably with influence upon some of the same cellular systems. At least two types of benzodiazepine receptors in the cerebrum have been described. These are presumed to be placed in the neighbourhood of gamma-aminobutyric-acid (GABA) receptors and they probably modify the functions of these. In addition, influence on other transmitter systems in the CNS occurs with release of adenosine and reduction of the acetyl choline content. It has been demonstrated that methylxanthines are adenosine-blocking but they also release catecholamines from the suprarenal cortex and sympathetic nerve-ends both centrally and peripherally. In clinical practice, the antagonistic effect of employing methylxanthines in patients sedated with benzodiazepines has been demonstrated. Administration of 1-2 mg/kg of aminophyllin usually results in immediate effect and these patients woke up immediately after injection. When benzodiazepines and methylxanthines are administered simultaneously the total result will be difficult to predict.
pubmed:language
dan
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0041-5782
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
803-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Methylxanthines and benzodiazepine antagonism].
pubmed:affiliation
Rigshospitalet, København, anaestesiafdelingen.
pubmed:publicationType
Journal Article, English Abstract, Review