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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-4-25
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pubmed:abstractText |
The Near-Death Experience (NDE) is a dissociative mental state with characteristic features. These can be reproduced by ketamine which acts at sigma sites and blocks N-methyl-D-aspartate (NMDA) linked phencyclidine (PCP) receptors to reduce ischaemic damage. Endogenous ligands, alpha and beta-endopsychosin, have been detected for these receptors which suggests an explanation for some NDE's: the endopsychosins may be released in abnormal quantity to protect neurons from ischaemic and other excitotoxic damage, and the NDE is a side effect on consciousness with important psychological functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, sigma,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-endopsychosin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-9877
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2156135-Consciousness,
pubmed-meshheading:2156135-Death,
pubmed-meshheading:2156135-Humans,
pubmed-meshheading:2156135-Ketamine,
pubmed-meshheading:2156135-Models, Neurological,
pubmed-meshheading:2156135-Neuropeptides,
pubmed-meshheading:2156135-Neurosciences,
pubmed-meshheading:2156135-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:2156135-Receptors, Neurotransmitter,
pubmed-meshheading:2156135-Receptors, Opioid,
pubmed-meshheading:2156135-Receptors, sigma
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pubmed:year |
1990
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pubmed:articleTitle |
Neuroscience and the near-death experience: roles for the NMSA-PCP receptor, the sigma receptor and the endopsychosins.
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pubmed:affiliation |
Department of Anatomy, University of Auckland Medical School, New Zealand.
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pubmed:publicationType |
Journal Article
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